Summary
Epoxidation of natural terpene (+)-carvone by the system consisting of a catalyst, oxalic acid (co-catalyst) and H2O2 (70% aqueous solution; oxidant) was studied and factorial design methods were applied for the optimization of this reaction. A dinuclear manganese(IV) complex [LMn(O)3MnL](PF6)2 (L = 1,4,7-trimethyl-1,4,7-triazacyclononane) was used as a catalyst, and acetonitrile was employed as a solvent. An analysis by methods of the complete 24 factorial design showed that an increase in the catalyst concentration gives a strong positive effect on the carvone conversion and selectivity. Hydrogen peroxide has a smaller positive effect on the conversion, but at high concentration, H2O2 leads to some decrease in the selectivity. An increase in the oxalic acid concentration has a beneficial effect on the conversion, but does not affect the selectivity.
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Mandelli, D., Steffen, R. & Shul'pin, G. Carvone epoxidation by system “hydrogen peroxide-[Mn 2 L 2 O 3 ][PF 6 ] 2 (L = 1,4,7-trimethyl-1,4,7-triazacyclononane)-carboxylic acid”: a combinatorial approach to the process optimization . React Kinet Catal Lett 88, 165–173 (2006). https://doi.org/10.1007/s11144-006-0124-1
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DOI: https://doi.org/10.1007/s11144-006-0124-1