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The impact of a neuromuscular rehabilitation programme on the quality of life of patients with acute coronary syndrome and its relationship with sexual dysfunction: a randomised controlled trial

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Abstract

Purpose

Many patients with acute coronary syndrome experience problematic or altered sexual function. This aspect of the disease is frequently ignored or overlooked by the healthcare community even though it can strongly influence health-related patient quality of life (HRQoL). Thus, the aim of this study was to compare the effects of a specific cardiac rehabilitation programme focused on aerobic and neuromuscular strength-resistance training to those of a classic rehabilitation programme, both in terms of HRQoL and erectile dysfunction in patients with acute coronary syndrome.

Methods

This study reports both secondary and unregistered outcomes from a double-blinded, randomised, and controlled clinical trial. The proposed intervention was based on the completion of a 20-session (10-week) cardiac rehabilitation programme for patients with cardiovascular disease. The patient cohort had been diagnosed with acute coronary syndrome and was recruited at the Cardiology Service of a private tertiary hospital. The outcomes assessed in this study were HRQoL and erectile disfunction assessed at baseline, after the intervention, and at a 6-month follow-up.

Results

A total of 30 participants were randomly allocated to each study arm. The results of the two-way mixed ANOVAs showed significant group × time interactions for all the outcome measures (EQ-5D_index, p = 0.004; EQ-5D_VAS, p = 0.017; QLMI-Q, p ≤ 0.001; and IIEF-5, p = 0.001).

Conclusion

The neuromuscular strength training programme was more effective than the classic strength training programme in terms of increasing the HRQoL and improving erectile dysfunction in patients following acute coronary syndrome, with differences still remaining between these groups at the 6-month follow-up.

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Data availability

Derived data supporting the findings of this study are available from the corresponding author MLLV on request.

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Author notes

  1. Noemí Valtueña-Gimeno and Francisco José Ferrer-Sargues have contributed equally to this work as first co-authors.

Authors and Affiliations

  1. Department of Nursing and Physiotherapy, Universidad Cardenal Herrera CEU, CEU Universities, Calle Santiago Ramón y Cajal, 20, 46115, Alfara del Patriarca, Valencia, Spain

    Noemí Valtueña-Gimeno, Francisco José Ferrer-Sargues, Isabel Martínez-Hurtado, F. J. Martínez-Olmos, Marta Lluesma-Vidal & María Dolores Arguisuelas

  2. Department of Medicine, Universidad Cardenal Herrera CEU, CEU Universities, Calle Santiago Ramón y Cajal, 20, 46115, Alfara del Patriarca, Valencia, Spain

    Oscar Fabregat-Andrés

  3. Department of Cardiology, Hospital IMED, Av. de la ilustración, 1, 46100, Burjassot, Valencia, Spain

    Oscar Fabregat-Andrés

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Contributions

Conceptualisation: VGN, F-SFJ, and L-VM; methodology: VGN, F-SFJ, and F-AÓ; patient selection and recruitment: F-SFJ and F-AÓ; rehabilitation training and outcomes: VGN, F-SFJ, L-VM, M-HI, and Martinez-Olmos, Francisco José; measures and data acquisition: VGN, L-VM, and AMD; software, validation, data curation and formal analysis: F-AÓ and AMD; writing (original draft preparation): F-SFJ and L-VM; writing (review and editing): F-AÓ, VGN, AMD, M-HI, and M-OFJ; visualisation, supervision, investigation, and resources: VGN, AMD, M-HI, and M-OFJ.

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Correspondence to Marta Lluesma-Vidal.

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Valtueña-Gimeno, N., Ferrer-Sargues, F.J., Fabregat-Andrés, O. et al. The impact of a neuromuscular rehabilitation programme on the quality of life of patients with acute coronary syndrome and its relationship with sexual dysfunction: a randomised controlled trial. Qual Life Res 33, 433–442 (2024). https://doi.org/10.1007/s11136-023-03534-7

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