Abstract
Brazilian arnicas belong to the Asteraceae family and can be mainly found in the Brazilian biome Cerrado (savanna) but also Caatinga, Atlantic Forest, Pampa, Pantanal, and Amazonia Forest. The plant’s leaves, roots, inflorescences, and flowers have demonstrated high medicinal potential use as evidenced by recent studies. The Brazilian arnica species were selected based on their ethnopharmacological representativeness, with the 9 most relevant species being identified: Calea uniflora Less, Chaptalia nutans (L.) Polák., Lychnophora ericoides Mart, L. pinaster Mart. and L. salicifolia Mart, Porophyllum ruderale (Jacq.) Cass., Pseudobrickellia brasiliensis (Spreng.) R.M. King & H. Rob. Solidago chilensis Meyen, Sphagneticola trilobata (L.) Pruski. Brazilian arnicas species have many pharmacological/bioactive constituents such as flavonoids, phenolic compounds, and terpenoids, especially monoterpenes, and sesquiterpenes. Experimental in vitro and in vivo studies indicate its benefits to prevent, improve and treat human conditions or diseases with several beneficial effects such as anti-inflammatory, analgesic, antiedematogenic, antimicrobial, antioxidant, trypanocidal, and leishmanicidal activity. Arnicas extracts and their bioactive compounds have been suggested as useful tools in the industry, for example, in topical formulations and green chemistry. Like many other native plants spread throughout Brazil, arnicas have a high functional potential that needs further exploration. In this context, the present review aims to describe the potential use of Brazilian arnicas, highlighting their geographic distribution, uses in traditional medicine, bioactive composition, health effects, and potential applications.
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This work was partially supported by the Coordenadoria de Aperfeiçoamento do Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).
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Marinho, B.M., Lescano, C.H. & Santos, S.H.S. Brazilian arnicas: bioactive compounds, pharmacological properties, potential use and clinical applications. Phytochem Rev 23, 245–280 (2024). https://doi.org/10.1007/s11101-023-09884-x
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DOI: https://doi.org/10.1007/s11101-023-09884-x