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Phytochemical and pharmacological studies in Pedalium murex L.

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Abstract

Pedalium murex (Pedaliaceae), commonly called Large Caltrops, is known for its pharmacological uses in traditional medicine system. It is reported to have excellent medicinal properties that helps cure reproductive disorders, mainly impotency in men, nocturnal emissions, gonorrhea as well as leucorrhoea in women. Apart from that, it also contains remedy for urinary and gastrointestinal tract disorders. Pharmacologically, the plant has been investigated for antiulcerogenic, nephroprotective, hypolipidemic, aphrodisiac, anti-inflammatory, antidermatophytic, antioxidant, antimicrobial and insecticidal activities. The present review is a bundle of information collected from the published research articles and highlights the phytochemical and pharmacological aspects of P. murex. The information will be helpful in developing the new formulation with therapeutic and economical value in the future.

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  1. http://www.britannica.com/plant/Pedaliaceae

  2. http://www.tropicos.org

References

  • Abirami P, Rajendran A (2015) Evaluation of antidermatophytic activity of Pedalium murex L. World J Pharma Res 4(3):1871–1881

    Google Scholar 

  • Adikay S, Latha JP, Koganti B (2010) Effect of fruits of Pedalium murex against cadmium chloride-induced nephrotoxicity in rats. Int J Drug Dev Res 2(2):40–46

    Google Scholar 

  • Agharkar SP (1991) Medicinal plants of Bombay presidency. Scientific Publishers, Jodhpur, pp 1–258

    Google Scholar 

  • Anandanayaki S (2010) Comparative pharmacognosticalstudies on selected plants, Ph.D., Tamil Nadu University

  • Anonymous (1966) The wealth of India, a dictionary of Indian raw materials and industrial products, vol 7. Raw Materials, CSIR, New Delhi, p 284

    Google Scholar 

  • Anubu K and Subramanian P (2011) Serial extraction of the crude extract: HPLC separation of the Lyophilized extracts: identification of major peaks and their elution in Hybathuseneasperusad Pedalium murex. In: An Anthology of Articles on Aquatic Research, Nitheesheeshjrabha Pathippagam Publisher, Karaikudi, pp 73–88

  • Arockiasamy S, Ramachandran V, Kuppaswamy KM (2012) Antiproliferative activity of methanolic fruit extract of Pedalium murex Linn against lung cancer cell line A549. J Pharm Res 5:2861–2866

    Google Scholar 

  • Babu MA, Srinivas P, Venkateshwarulu L, Anil Kumar C (2011) Antioxidant activity of Pedalium murex fruits in carbon tetrachloride-induced hepatopathy in rats. Int J Pharm Biosci 2(1):622–628

    Google Scholar 

  • Balakrishnan V, Prema P, Ravindran KC, Robinson JP (2009) Ethnobotanical Studies among villagers from Dharapuram Taluk, Tamil Nadu, India. Glob J Pharmacol 3(1):8–14

    Google Scholar 

  • Balamurugan G, Muralidharan P, Polapala S (2010) Aphrodisiac activity and curative effects of Pedalium murex (L) against ethanol induced infertility in male rats. Turk J Biol 34(2):153–163

    Google Scholar 

  • Balasubramanian MN, Muralidharan P, Balamurugan G (2008) Anti hyperlipidemic activity of Pedalium murex (Linn.) fruits inhigh-fat diet fed rats. Int J Pharmacol 4(4):310–313

    Article  Google Scholar 

  • Banji D, Singh J, Banji OJ, Shanthamurthy M (2010) Scrutinizing the aqueous extract of leaves of Pedalium murex for the antiulcer activity in rats. Pak J Pharm Sci 23(3):295–299

    PubMed  Google Scholar 

  • Bhakuni RS, Shukla YN, Thakur RS (1992) Flavonoids and other constituents from Pedalium murex. Phytochemistry 31:2917–2918

    Article  CAS  Google Scholar 

  • Brei B, Edman JD, Gerade B, Clark JM (2004) Relative abundance of two cuticular hydrocarbons indicates whether a mosquito is old enough to transmit malaria parasites. J Med Entomol 41(4):807–809

    Article  CAS  PubMed  Google Scholar 

  • Chan BG, Waiss AC, Binder RG, Elliger CA (1978) Inhibition of lepidopterous larval growth by cotton constituents. Entomol Exp Appl 24:294–300

    Article  CAS  Google Scholar 

  • Chitra T, Murugan K, Naresh Kumar A, Madhiyazhagan P, Nataraj T, Indumathi D, Hwang JS (2013) Laboratory and field efficacy of Pedalium murex and Predatory copepod, Mesocyclops longisetus on rural malaria vector, Anopheles culicifacies. Asian Pac J Trop Dis 3(2):111–118

    Article  PubMed Central  Google Scholar 

  • Chopra RN, Nayar SL, Chopra IC (1956) Glossary of Indain medicinal plants, vol 20, 1st edn. National Institute of Science Communication (C.S.I.R), New Delhi, p 330

    Google Scholar 

  • Das VSR, Rao KN, Rao JVS (1966) Phenolic acid in some members of Pedaliaceae. Curr Sci 35:160

    CAS  Google Scholar 

  • Dey D, Das MN (1995) Pharmacognostical studies of root and fruit of Gokshura (Pedalium murex Linn.). BMEBR 16(1–2):54–65

    Google Scholar 

  • Dianat M, Radan M, Badavi M, Sarkaki A (2014) The evaluation of inotropic properties and antidysrhythmic effect of vanillic acid and exercise on CaCl2—induced arrhythmia in young and aged rats. Res J Pharm Biol Chem Sci 5(3):1545–1555

    CAS  Google Scholar 

  • Elumalai A, Eswaraiah C, Munna N, Vanamala S, Manadala N (2011) A review on the therapeutic uses of Pedalium murex linn. Int J Res Ayurveda Pharm 2(6):1743–1745

    CAS  Google Scholar 

  • Fazli FRY, Hardman R (1968) The spice, fenugreek, (Trigonella foenumgraecum): its commercial var. of seed as a source of diosgenin. Trop Sci 10:66–68

    CAS  Google Scholar 

  • Gupta AK, Tandon N, Sharma M (eds) (2006) Quality standards of Indian Medicinal Plants, vol 4. Indian Council of Medical Research, New Delhi, pp 178–184

  • Heble MR, Narayanaswami S, Chadha MS (1968) Disogenin and β—sterol isolation from Solanum xanthocarpum tissue cultures. Science 161:1145

    Article  CAS  PubMed  Google Scholar 

  • Imran M, Kumar N, Nohri F, Kumar D, Kousar T, Sultan MT, Ilyas SA, Shahida S (2015) Phytochemical and pharmacological potentials of Pedalium murex Linn and its traditional medicinal uses. J Coast Life Med 3(9):737–743

    Article  CAS  Google Scholar 

  • Jain A, Katewa SS, Chaudhary BL, Galav P (2004) Folk herbal medicines used in birth control and sexual diseases by tribals of southern Rajastha, India. J Ethnopharmacol 90(1):171–177

    Article  PubMed  Google Scholar 

  • Jenifer S, Laveena DK, Priya S, Singh SJS, Jeyasree J (2014) Antimicrobial screening of Euphorbia hirta L. and Pedalium murex L.—a comparative study. World J Pharm Pharm Sci 3(12):1221–1226

    Google Scholar 

  • Kalyani R, Khanpara K, Shukla VJ, Prajapati PK (2012) A study to evaluate “Diosgenin” in Laghu gokshur (T. terrestries) and Brihat gokshur (Pedalium murex) by HPTLC method. Int J Pharm Biol Arch 3(5):1117–1120

    Google Scholar 

  • Kasim SM, Neelakantan S, Raman PV (1975) Chemical components of Indian medicinal plants [Thespesia populnea wood Calycoscris and floribunda flowers]. Curr Sci 44:888–889

    Google Scholar 

  • Katewa SS, Chaudhary BL, Jain A (2004) Folk herbal medicines from tribal area of Rajasthan, India. J Ethnopharmacol 92(1):41–46

    Article  CAS  PubMed  Google Scholar 

  • Khare CP (2007) Indian medicinal plants: an illustrated dictionary. Springer-Verlag, Berlin/Heidelberg, pp 468–469

    Google Scholar 

  • Kim SJ, Kim MC, Um JY, Hong SH (2010) The beneficial effect of vanillic acid on ulcerative colitis. Molecules 15:7208–7217

    Article  CAS  PubMed  Google Scholar 

  • Kirtikar KR, Basu BD, An ICS (1980) Indian medicinal plants, vol 3.  Prabasi Press, Calcutta, pp 1856–1857

    Google Scholar 

  • Krishnaswamy NR, Seshadri TR, Tahir PJ (1970) Flavone glucosides of Nepetah industana and Sesamum indicum: nepitrin and pedaliin and theiraglucones. Ind J Chem 8:1074–1078

    CAS  Google Scholar 

  • Kshirsagar VB, Deokate UA, Bharkad VB, Khadabadi SS (2008) HPTLC method development and validation for the simultaneous estimation of diosgenin and Levodopa in marketed formulation. Asian J Res Chem 1:36–39

    CAS  Google Scholar 

  • Lambert N, Baccou JC, Sauvaire Y (1988) Screening for diosgenin in rhizomes from 3 Costus species (C. deistellii, C. igneous, C. lucanusianus). Planta Med 54:366–367

    Article  CAS  PubMed  Google Scholar 

  • Levin E (1963) Effects of octacosanol on chick comb growth. Proc Soc Exp Biol Med 112:331–334

    Article  CAS  PubMed  Google Scholar 

  • Lin Y, Shi R, Wag X, Shen H (2008) Luteolin, a flavonoid with potentials for cancer prevention and therapy. Curr Cancer Drug Targets 8(7):634–646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ma CM, Cai SQ, Cui JR, Wang RQ, Tu PF, Hattori M, Daneshtalab M (2005) The cytotoxic activity of ursolic acid derivatives. Eur J Med Chem 40(6):582–589

    Article  CAS  PubMed  Google Scholar 

  • Mangle MS, Jolly CI (1998) HPTLC studies on Tribulus terrestris L. (Chota Gokhru) and P. murex L. (Bada Gokhru). Indian Drugs 35(4):189–194

    CAS  Google Scholar 

  • Mukherjee PK (2002) Quality control of herbal drugs: an approach of evaluation of botanicals. Business Horizons Publishers, New Delhi, p 800

    Google Scholar 

  • Mukundh N, Balasubramanian P, Muralidharan P, Balamurgan G (2008) Anti-hyperlipidemic activity of Pedalium murex Linn. fruits on high fat diet fed rats. Int J Pharmacol 4(4):310–313

    Article  Google Scholar 

  • Muralidharan P, Balamurugan G (2008) Analgesic and anti-inflammatory activities of aqueous extract of Pedalium murex Linn. Biomed 28:84–87

    Google Scholar 

  • Muruganatham S (2011) In vitro anti-bacterial activity of P. murex L. Int J Univ Pharm Life Sci 1(2):37–44

    Google Scholar 

  • Nadanakunjidam S (2004) Folklore plants used in veterinary medicine by tribals of Attapadi Western Ghats. Adv Plant Sci 17(1):61–65

    Google Scholar 

  • Nair NC, Chithra V, Henry AN, Kumari GR (1983) Flora of Tamil Nadu, India series-1. Botanical Survey of India, Coimbatore. 1–3:11

  • Ojha ML, Chadha NK, Saini VP, Damroy S, Gupta CP, Savant PB (2014) Effect of ethanolic extract of Pedalium murex on growth and Haemato immunological parameters of Labeo rohita. Proc Nat Acd Sci, India Sec B: Biol Sci 84(4):997–1003

    Article  Google Scholar 

  • Olayemi JO, Ayaiyeoba EO (2007) Anti-inflammtory studies of yam (Dioserea esculenta) extract on Wister rats. Afr J Biotecnol 6:1913–1915

    Article  Google Scholar 

  • Parimelazhagan T (2001) Botanical fungicide for the control of rice blast disease. Bioved 12:11–15

    Google Scholar 

  • Patel DK, Kumar R, Prasad SK, Hemlatha S (2011) Pedalium murex Linn (Pedaliaceae) fruits: a comparative antioxidant activity of its different fractions. Asian Pac J Trop Biomed 1(5):395–400

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patel DK, Kumar R, Laloo D, Sairam K, Hemalatha S (2012) Aphrodisiac activity of ethanolic extract of Pedalium murex Linn fruit. Asian Pac J Trop Biomed 2:S1568–S1571

    Article  Google Scholar 

  • Patel MK, Mandavia DR, Patel TK, Barvaliya MJ, Tripathi CB (2013) Evaluation of anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. Fruits. Afr J Tradit Complement Altern Med 10(4):94–100

    PubMed  PubMed Central  Google Scholar 

  • Prabhakaran D, Rajeshkanna A, Senthamilselvi MM (2016) Antimicrobial activity of Pedalium murex (Flowers). Indo Am J Pharm Res 6(4):5118–5122

    CAS  Google Scholar 

  • Prasad TNV, Sastry KV (1989) A note on the chemical examination of P. murex leaves. Ind Drugs 25(2):84

    Google Scholar 

  • Prince PSM, Rajkumar S, Dhanasekar K (2011) Protective effects of vanillic acid on electrocardiogram, lipid peroxidation, antioxidants, proinflammatory markers and histopathology in isoproterenol induced cardiotoxic rats. Eur J Pharmacol 668:233–240

    Article  CAS  Google Scholar 

  • Raja M, William SJ, Jayakumar M (2007) Repellent activity of plant extracts against pulse beetle Callosobruchus maculatus (Fab.) (Coleoptera: Bruchidae). Hexapoda 14(2):142–145

    Google Scholar 

  • Rajashekar V, Rao EU, Srinivas P (2012) Biological activities and medicinal properties of Gokhru (Pedalium murex L.). Asian Pac J Trop Biomed 2(7):581–585

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rao PU (1994) Nutrient composition of some less-familiar oil seeds. Food Chem 50(4):379–382

    Article  CAS  Google Scholar 

  • Sahayaraj K, Alakiaraj RJ, Borgio JF (2006) Ovicidal and ovipositional effect of Pedalium murex Linn. (Pedaliaceae) root extracts on Dysdercus cingulatus (Fab.) (Hemiptera: Pyrrhocoridae). Entomon 3(1):57–60

    Google Scholar 

  • Sahayaraj K, Venkateshwari M, Balasubramanian R (2008) Insecticidal and anti-feedent effect of P. murex root and on Spodoptera litura (Lepidoptera: Noctuidae). J Agric Technol 4(2):73–80

    Google Scholar 

  • Sahu M, Vermaand D, Harris KK (2014) Phytochemical analysis of the leaf, stem and seed extracts of Cajanus cajan (dicotyledoneae: fabaceae). World J Pharm Pharm Sci 3(8):694–733

    Google Scholar 

  • Sermakkani M (2011) Evaluation of phytochemical and antibacterial activity of P murex Linn Root. Int Res J Phrm 2(3):131–134

    Google Scholar 

  • Shah HJ, Lele SS (2012) Extraction of diosgenin, a bioactive compound from natural source Dioscorea alata var purpurae. J Anal Bioanal Tech 3(4):141

    Article  CAS  Google Scholar 

  • Sharma P, Sarin R (2012) Isolation and characterization of quercetin and kaempferol in vivo and in vitro from Pedalium murex. Int Res J Pharm 3(6):184–187

    CAS  Google Scholar 

  • Sharma V, Thakur M, Dixit VK (2012) A comparative study of ethanolic extracts of Pedalium murex Linn. fruits and sildenafil citrate on sexual behaviors and serum testosterone level in male rats during and after treatment. J Ethnopharacol 143:201–206

    Article  CAS  Google Scholar 

  • Shelke TT, Kothai R, Adkar PP, Bhaskar VH, Juvale KC, Kamble BB, Oswal RJ (2009) Nephroprotective activity of ethanolic extract of dried fruits of Pedalium murex Linn. J Cell Tissue Res 9(1):1687–1690

    Google Scholar 

  • Shukla YN, Khanuja SPS (2004) Chemical, pharmacological and botanical studies on Pedalium murex. J Med Aromat Plant Sci 26:64–69

    CAS  Google Scholar 

  • Shukla VN, Thakur RS (1983) Heptatriacontan-4-one, Tetratriacontanyl octacosanoate and other constitutes from Pedalium murex L. Phytochemistry 22:973–974

    Article  CAS  Google Scholar 

  • Singh MP, Panda H (2005) Medicinal herbs with their formulation. Daya publishing House, New Delhi, p 637

    Google Scholar 

  • Sithanantham S, Ballal CR, Jalali SK, Bakthavatsalam N (2013) Biological control of insects pest using egg parasitoides, vol 2. Springer Science and Business Media, New Delhi, p 422

    Book  Google Scholar 

  • Sivarajan VV, Balachandran I (1994) Ayurvedic drugs and their plant sources. Oxford and IBH publishing, p 570

  • Soosairaj S, Natarajan D, Nagamurugan N, Radha B (2008) Aspergillosidal effect of Pongamia glabra and Pedalium murex a comparative study. J Phytol Res 21(2):221–224

    Google Scholar 

  • Srinivas P, Reddy SR (2014) Screening for antibacterial principal and activity of Pedalium murex Linn. Proc Natl Acad Sci India B Biol Sci 84(4):1083–1090

    Article  CAS  Google Scholar 

  • Stapf O (1905) Flora of tropical Africa. R Bot Gard Kew 4(2):538

    Google Scholar 

  • Subramanian SS, Nair AGR (1972) Flavonoids of the leaves of Pedalium murex. Phytochemistry 11:464–465

    Article  CAS  Google Scholar 

  • Suresh P, Janarthanan S, Selvarani S (2002) Effect of certain phytochemical on larva of Spodoptera litura (Fabricius). In: Paper presented in Sanjayan KP, Mahalingam V, Muralirangan MC (eds) Vistas of entomological Research for the New Millennium. pp 85–87

  • Suthar A, Mulani RM, Gulati V (2008) A HPTLC method for estimation of solasodine and diosgenin in Solanum xanthocarpum Schrad and Wendl. Nat Prod Indian J 4(1):108–112

    CAS  Google Scholar 

  • Tapiero H, Tew KD, Ba GN, Mathe G (2002) Polyphenols: do they play a role in the prevention of human pathologies? Biomed Pharmacother 56:200–207

    Article  CAS  PubMed  Google Scholar 

  • Thakkar JH, Solanki AN, Thakkar MH, Solanki HK, Patel NJ (2011) In vitro antioxidant activity of aqueous fruit extract of Pedalium murex L. Int J Preclin Pharm Res 2:26–29

    Google Scholar 

  • Thamizhmozhil M, Mulaicharam AR, Murugesh S (2011) Phytochemical and pharmacognostical studies on Pedalium murex Linn. Int J Res Ayurveda Pharm 2(1):253–258

    Google Scholar 

  • Upadhyay B,  Dhaker PAK, Kumar A (2010) Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan India. J Ethnopharmacol 129(1):64–86

    Article  PubMed  Google Scholar 

  • Valenzuela A, Sanhueza J, Nieto S (2003) Natural antioxidants in functional foods: from food safety to health benefits. Grasas y Aceites 54:295–303

    Article  Google Scholar 

  • Venkatarathina KT, Muthusamy VA, Ramanathan S (2005) Evaluation of the petroleum ether extracts of P. murex against Japanese encephalitis vector Culex tritaenlorhynchus. Antiseptic 102:335–336

    Google Scholar 

  • Wang HK (2000) The therapeutic potential of flavonoids. Expert Opin Investig Drugs 9:2103–2119

    Article  CAS  PubMed  Google Scholar 

  • Watt G (1985) Dictionary of the economic products of India. Goverment Printing, Culcutta, p 597

    Google Scholar 

  • Zhang L, Zhang Y, Zhang L, Yang X, Lv Z (2009) Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis, through down regulation of DR3 in SMMC7721 cells. Cancer Investig 27:163–170

    Article  CAS  Google Scholar 

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Acknowledgements

GC thanks to UGC Women’s Post Doctorate Fellowship, for financial support of the project.

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  1. Plant Biotechnology, Environmental and Industrial Biotechnology Division, The Energy and Resources Institute (TERI), Darbari Seth Block, India Habitat Centre, Lodhi Road, New Delhi, 110 003, India

    Gulshan Chaudhary & Nutan Kaushik

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  1. Gulshan Chaudhary
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Correspondence to Nutan Kaushik.

Glossary

Aphrodisiac

Thing that stimulates sexual desire

Caltrops

Spines arranged in such a manner that one of them always points upward from a stable base

Diuretic

Causing increased passing of urine

DPPH

1,1-Diphenyl-2-picryl-hydrazyl

Dysuria

Painful or difficult urination

Emmenagogue

A substance that stimulates or increases menstrual flow

Gleet

A watery discharge from the urethra caused by gonorrhoeal infection

Gonorrhea

Sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae

Leucorrhoea

A whitish or yellowish discharge of mucus from the vagina

Lumbago

Pain in the muscles and joints of the lower back

Piles

Hemorrhoids that become inflamed

P.O

Per os is an adverbial phrase meaning literally from Latin “by opening” or “by way of the opening.”

Slidenafild

Used to treat erectile dysfunction and pulmonary arterial hypertension

Stomachic

Promoting the appetite or assisting digestion

Strangury

A condition caused by blockage or irritation at the base of the bladder, resulting in severe pain and a strong desire to urinate

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Chaudhary, G., Kaushik, N. Phytochemical and pharmacological studies in Pedalium murex L.. Phytochem Rev 16, 921–934 (2017). https://doi.org/10.1007/s11101-017-9499-z

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