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Effects of multidisciplinary teams and an integrated follow-up electronic system on clinical pharmacist interventions in a cancer hospital

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Abstract

Background The aim of drug therapy is to attain distinct therapeutic effects that not only improve patient’s quality of life but also reduce the inherent risks associated with the therapeutic use of drugs. Pharmacists play a key role in reducing these risks by developing appropriate interventions. Whether to accept or reject the intervention made by the pharmacist is a relevant consultant’s decision. Objective To evaluate the impact of electronic prompts and follow-up of rejected pharmacy interventions by clinical pharmacists in an in-patient setting. Setting Shaukat Khanum Cancer Hospital & Research Center, Lahore, Pakistan. Method The study was conducted in two phases. Data for 3 months were collected for each phase of the study. Systematic and quantifiable consensus validity was developed for rejected interventions in phase 1, based on patient outcome analyses. Severity rating was assigned to assess the significance of interventions. Electronic prompts for follow-on interventions in phase 2 were then developed and implemented, including daily review via a multidisciplinary team (MDT) approach. Main outcome measure Validity of rejected interventions, acceptance of follow-on interventions before and after re-engineering the pharmacy processes, rejection rate and severity rating of follow-on interventions. Result Of a total of 2649 and 3064 interventions that were implemented during phase 1 and phase 2, 238 (9%) and 307 (10%) were rejected, respectively. Additionally, 133 (56%) were inappropriate rejections during phase 1. The estimated reliability between pharmacists regarding rejected interventions was 0.74 (95% CI of 0.69, 0.79, p 0.000). Prospective data were analysed after implementing electronic alerts and an MDT approach. The acceptance rate of follow-on interventions in phase 2 was 60% (184). Conclusion Electronic prompts for follow-on interventions together with an MDT approach enhance the optimization of pharmacotherapy, increase drug rationality and improve patient care.

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References

  1. Kucukarslan SN, Peters M, Mlynarek M, Nafziger DA. Pharmacists on rounding teams reduce preventable adverse drug events in hospital general medicine units. Arch Intern Med. 2003;163:2014–8.

    Article  PubMed  Google Scholar 

  2. Leape LL, Cullen DJ, Clapp MD, Burdick E, Demonaco HJ, Erickson JI, et al. Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA. 1999;282:267–70.

    Article  CAS  PubMed  Google Scholar 

  3. Bond CA, Raehl CL. Clinical pharmacy services, pharmacy staffing, and adverse drug reactions in United States hospitals. Pharmacotherapy. 2006;26:735–47.

    Article  CAS  PubMed  Google Scholar 

  4. Kaboli PJ, Hoth AB, McClimon BJ, Schnipper JL. Clinical pharmacists and inpatient medical care: a systematic review. Arch Intern Med. 2006;166:955–64.

    Article  PubMed  Google Scholar 

  5. Viktil KK, Blix HS. The impact of clinical pharmacists on drugrelated problems and clinical outcomes. Basic Clin Pharmacol Toxicol. 2008;102:275–80.

    Article  CAS  PubMed  Google Scholar 

  6. Calabretto J-P, Warren J, Bird L. Pharmacy decision support: where is it? A systematic literature review. Int J Pharm Pract. 2005;13:157–64.

    Article  Google Scholar 

  7. Sacchetti A, Sacchetti C, Carraccio C, Gerardi M. The potential for errors in children with special health care needs. Acad Emerg Med. 2000;7:1330–3.

    Article  CAS  PubMed  Google Scholar 

  8. Garg AX, Adhikari NK, McDonald H, Rosas-Arellano MP, Devereaux PJ, Beyene J, et al. Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA. 2005;293:1223–38.

    Article  CAS  PubMed  Google Scholar 

  9. Saleem JJ, Patterson ES, Militello L, Render ML, Orshansky G, Asch SM. Exploring barriers and facilitators to the use of computerized clinical reminders. J Am Med Inform Assoc. 2005;12:438–47.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Annemie S, Hugo R, De Paepe P, Georges VM, Perehudoff K, Mirko R. Evaluation of clinical pharmacist recommendations in the geriatric ward of a Belgian university hospital. Clin Interv Aging. 2013;8:703–9. doi:10.2147/CIA.S42162.

    Google Scholar 

  11. Graabæk T, Lene JK. Medication reviews by clinical pharmacists at hospitals lead to improved patient outcomes: a systematic review. Basic Clin Pharmacol Toxicol. 2013;112:359–73.

    Article  PubMed  Google Scholar 

  12. Bergkvist A, Midlov P, Hoglund P, Larsson L, Eriksson T. A multi-intervention approach on drug therapy can lead to a more appropriate drug use in the elderly. LIMM-Landskrona Integrated Medicines Management. J Eval Clin Pract. 2009;15:660–7.

    Article  PubMed  Google Scholar 

  13. Patient Statistics. Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore, Pakistan. 2016. https://www.shaukatkhanum.org.pk/about-us/statistics-gg/patient-statistics.html. Accessed 10 May 2016.

  14. Lisby M, Thomsen A, Nielsen LP, Lyhne NM, Breum-Leer C, Fredberg U, et al. The effect of systematic medication review in elderly patients admitted to an acute ward of internal medicine. Basic Clin Pharmacol Toxicol. 2010;106:422–7.

    CAS  PubMed  Google Scholar 

  15. Allan EL, Barker KN. Fundamentals of medication error research. Am J Hosp Pharm. 1990;47:555–71.

    CAS  PubMed  Google Scholar 

  16. Dooley MJ, Allen KM, Doecke CJ, Galbraith KJ, Taylor GR, Bright J, et al. A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals. Br J Clin Pharmacol. 2004;57:513–21.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Faisal S, Muhammad TA, Idrees K, Hussain Q, Manzar A, Amir M, et al. Development of an in-house hospital information system in a hospital in Pakistan. Int J Med Inf. 2014;83(3):180–8.

    Article  Google Scholar 

  18. Bladh L, Ottosson E, Karlsson J, Klintberg L, Wallerstedt SM. Effects of a clinical pharmacist service on health-related quality of life and prescribing of drugs: a randomised controlled trial. BMJ Qual Saf. 2011;20:738–46.

    Article  PubMed  Google Scholar 

  19. Al SZ. Clinical audit of pharmaceutical care provided by a clinical pharmacist in cardiology and infectious disease inpatients at the Royal Hospital, Muscat/Oman. Oman Med J. 2009;24:89–94.

    Google Scholar 

  20. Bergkvist Christensen A, Holmbjer L, Midlov P, Hoglund P, Larsson L, Bondesson A, et al. The process of identifying, solving and preventing drug related problems in the LIMM-study. Int J Clin Pharm. 2011;33:1010–8.

    Article  PubMed  Google Scholar 

  21. Gillespie U, Alassaad A, Henrohn D, Garmo H, Hammarlund-Udenaes M, Toss H, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med. 2009;169:894–900.

    Article  PubMed  Google Scholar 

  22. Pham DQ. Evaluating the impact of clinical interventions by PharmD students on internal medicine clerkships: the results of a 3 year study. Ann Pharmacother. 2006;40:1541–5.

    Article  PubMed  Google Scholar 

  23. Cerulli J, Malone M. Assessment of drug-related problems in clinical nutrition patients. JPEN J Parenter Enteral Nutr. 1999;23:218–21.

    Article  CAS  PubMed  Google Scholar 

  24. Mutnick AH, Sterba KJ, Peroutka JA, Sloan NE, Beltz EA, Sorenson MK. Cost savings and avoidance from clinical interventions. Am J Health Syst Pharm. 1997;54:392–6.

    CAS  PubMed  Google Scholar 

  25. Dorevitch A, Perl E. The impact of clinical pharmacy intervention in a psychiatric hospital. J Clin Pharm Ther. 1996;21:45–8.

    Article  CAS  PubMed  Google Scholar 

  26. Aburuz SM, Bulatova NR, Yousef AM, Al-Ghazawi MA, Alawwa IA, Al-Saleh A. Comprehensive assessment of treatment related problems in hospitalized medicine patients in Jordan. Int J Clin Pharm. 2011;33:501–11.

    Article  PubMed  Google Scholar 

  27. Blix HS, Viktil KK, Moger TA, Reikvam A. Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams. Pharm World Sci. 2006;28:152–8.

    Article  PubMed  Google Scholar 

  28. Munk CL, Bendixen HK, Kjeldsen LJ. Medication review with a focus on fracture prophylaxis among patients suffering collum femoris fractures. EJHP Pract. 2011;17:26–30.

    Google Scholar 

  29. Boso-Ribelles V, Montero-Hernandez M, Font-Noguera I, Hernandez- Martin J, Martin-Ciges ES, Poveda-Andres JL. Evaluation of a plan for cardiology medication reconciliation on admission, and patient information at discharge, in a teaching hospital. EJHP Pract. 2011;17:2011–30.

    Google Scholar 

  30. Kjeldsen LJ, Olesen C, Truelshøj T, Nielsen LB. Quality assurance of medical treatment—an approach by Danish clinical pharmacists. EJHP Pract. 2011;17:31–4.

    Google Scholar 

  31. O’Dell KM, Kucukarslan SN. Impact of the clinical pharmacist on readmission in patients with acute coronary syndrome. Ann Pharmacother. 2005;39:1423–7.

    Article  PubMed  Google Scholar 

  32. Spinewine A, Swine C, Dhillon S, Lambert P, Nachega JB, Wilmotte L, et al. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial. J Am Geriatr Soc. 2007;55:658–65.

    Article  PubMed  Google Scholar 

  33. Strong DK, Tsang GW. Focus and impact of pharmacists’ interventions. Can J Hosp Pharm. 1993;46:101–8.

    CAS  PubMed  Google Scholar 

  34. Laivenieks N, McCaul K, O’Brodovich M. Clinical pharmacy services provided to an emergency department. Can J Hosp Pharm. 1992;45:113–5.

    CAS  PubMed  Google Scholar 

  35. Castelino RL, Sathvik BS, Parthasarathi G, Gurudev KC, Shetty MS, Narahari MG. Prevalence of medication-related problems among patients with renal compromise in an Indian hospital. J Clin Pharm Ther. 2011;36:481–7.

    Article  CAS  PubMed  Google Scholar 

  36. Khalili H, Farsaei S, Rezaee H, Dashti-Khavidaki S. Role of clinical pharmacists’ interventions in detection and prevention of medication errors in a medical ward. Int J Clin Pharm. 2011;33:281–4.

    Article  PubMed  Google Scholar 

  37. Lada P, Delgado G Jr. Documentation of pharmacists’ interventions in an emergency department and associated cost avoidance. Am J Health Syst Pharm. 2007;64:63–8.

    Article  PubMed  Google Scholar 

  38. Chan DS, Kotzin DA. Adult vs pediatric clinical intervention trends: a four year, retrospective report. J Pediatr Pharm Pract. 1998;3:144–9.

    Google Scholar 

  39. Lal LS, Anassi EO, McCants E. Documentation of the first steps of pediatric pharmaceutical care in a county hospital. Hosp Pharm. 1995;30:1107–8.

    CAS  PubMed  Google Scholar 

  40. Bates D. Patient safety research introductory course Session 1. What is patient safety? Geneva: World Health Organization. 2010. http://www.who.int/patientsafety/research/ps_online_course_session1_intro_2in1_english_2010_en.pdf. Accessed 26 Mar 2016.

  41. Wilson RM, Michel P, Olsen S, Gibberd RW, Vincent C, El-Assady R, et al. Patient safety in developing countries: retrospective estimation of scale and nature of harm to patients in hospital. BMJ. 2012;344:e832.

    Article  CAS  PubMed  Google Scholar 

  42. Tully M, Buchan I. Prescribing errors during hospital inpatient care: factors influencing identification by pharmacists. Pharm World Sci. 2009;31:682–8.

    Article  PubMed  Google Scholar 

  43. Van den BP, Fijn R, Van der VP, Gossen AA, Egberts TC, Brouwers JR. Frequency, determinants of drug administration errors in the intensive care unit. Crit Care Med. 2002;30:846.

    Article  Google Scholar 

  44. Bond CA, Raehl CL. National clinical pharmacy services survey: clinical pharmacy services, collaborative drug management, medication errors, and pharmacy technology. Pharmacotherapy. 2008;28:1–13.

    Article  CAS  PubMed  Google Scholar 

  45. Dashti-Khavidaki S, Khalili H, Hamishekar H, Shahverdi S. Clinical pharmacy services in an Iranian teaching hospital: a descriptive study. Pharm World Sci. 2009;31:696–700.

    Article  PubMed  Google Scholar 

  46. Costello J, Torowicz D, Yeh T. Effects of a pharmacist-led pediatrics medication safety team on medication-error reporting. Am J Health Syst Pharm. 2007;64:1422–6.

    Article  PubMed  Google Scholar 

  47. Brown J, Barnes C, Beasley B, Cisneros R, Pound M, Herring C. Effect of pharmacists on medication errors in an emergency department. Am J Health Syst Pharm. 2008;65:330–3.

    Article  PubMed  Google Scholar 

  48. Vessal G. Detection of prescription errors by a unit-based clinical pharmacist in a nephrology ward. Pharm World Sci. 2010;32:59–65.

    Article  PubMed  Google Scholar 

  49. Eggink R, Lenderink A, Widdrshoven J, Bemt P. The effect of a clinical pharmacist discharge service on medication discrepancies in patients with heart failure. Pharm World Sci. 2010;32(6):759–66. doi:10.1007/s11096-010-9433-6.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Hussain MA, Raid MA, Havagiray RC. Interventions by pharmacists in out-patient pharmaceutical care. Saudi Pharm J. 2014;22:101–6.

    Article  Google Scholar 

  51. Krahenbuhl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Krahenbuhl S. Drug-related problems in hospitals: a review of the recent literature. Drug Saf. 2007;30:379–407.

    Article  PubMed  Google Scholar 

  52. Schneeweiss S, Hasford J, Gottler M, Hoffmann A, Riethling AK, Avorn J. Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study. Eur J Clin Pharmacol. 2002;58:285–91.

    Article  PubMed  Google Scholar 

  53. Koshman SL, Charrois TL, Simpson SH, McAlister FA, Tsuyuki RT. Pharmacist care of patients with heart failure: a systematic review of randomized trials. Arch Intern Med. 2008;168:687–94.

    Article  PubMed  Google Scholar 

  54. Bates DW, Kuperman GJ, Wang S, Gandhi T, Kittler A, Volk L, et al. Ten commandments for effective clinical decision support: making the practice of evidence-based medicine a reality. J Am Med Inf Assoc. 2003;10:523–30.

    Article  Google Scholar 

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Acknowledgement

The author thanks all the clinical pharmacists for their help with obtaining background information on pharmacy interventions.

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Correspondence to Muhammad Tahir Aziz.

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Aziz, M.T., Rehman, T.U., Qureshi, S. et al. Effects of multidisciplinary teams and an integrated follow-up electronic system on clinical pharmacist interventions in a cancer hospital. Int J Clin Pharm 39, 1175–1184 (2017). https://doi.org/10.1007/s11096-017-0530-7

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