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Mapping Ion-Induced Mesophasic Transformation in Lyotropic In Situ Gelling System and its Correlation with Pharmaceutical Performance

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Abstract

Purpose

To investigate influence of ion induced mesophasic transformation on pharmaceutical performance of in situ gelling system consisting of glyceryl monooleate.

Methods

The prepared system showed mesophasic transformation during its conversion from sol to gel upon controlled hydration. The process of mesophasic transformation was studied by SAXS, DSC, rheology and plane polarized light microscopy. Further the influence of additives i.e. naproxen salts (sodium and potassium) and naproxen (base) on the process of mesophasic transformation was also elucidated.

Results

It was observed that addition of salt form of naproxen transformed W/O emulsions into cubic mesophase whereas addition of base form of naproxen formed reverse hexagonal (HII) phase upon controlled hydration. The cubic mesophase formed by naproxen salts retarded the drug release for initial 3 h whereas HII phase showed sustained drug release characteristics for naproxen base following Higuchi drug release kinetics.

Conclusion

The current work suggests that formulations with tailor made pharmaceutical performance can be developed by selecting proper additives in the system so as to obtain the desired mesophase ‘on demand’ thereby controlling drug release characteristics.

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Acknowledgments And Disclosures

The authors thank Dr. Guruswamy Kumaraswamy, Scientist, Polymer Chemistry, National Chemical Laboratory, Pune for providing facility of Small Angle X ray Scattering and for extending his cooperation in SAXS data analysis and discussion.

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Authors and Affiliations

  1. Poona College of Pharmacy, Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Erandwane, Pune, 411 038, Maharashtra, India

    Sharvil S. Patil & Kakasaheb R. Mahadik

  2. Polymer Science and Engineering Division, National Chemical Laboratory, Pune, 411 008, India

    Sharvil S. Patil, Edakkal Venugopal & Suresh Bhat

  3. Centre for Pharmaceutical Engineering Science, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK

    Anant R. Paradkar

Authors
  1. Sharvil S. Patil
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  2. Edakkal Venugopal
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  3. Suresh Bhat
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  4. Kakasaheb R. Mahadik
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  5. Anant R. Paradkar
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Correspondence to Kakasaheb R. Mahadik or Anant R. Paradkar.

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Patil, S.S., Venugopal, E., Bhat, S. et al. Mapping Ion-Induced Mesophasic Transformation in Lyotropic In Situ Gelling System and its Correlation with Pharmaceutical Performance. Pharm Res 30, 1906–1914 (2013). https://doi.org/10.1007/s11095-013-1033-4

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  • DOI: https://doi.org/10.1007/s11095-013-1033-4

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