Purpose
The aim of the study is to optimize the intercalation conditions of ferulic acid (FERH), an antioxidant compound, into Mg–Al–hydrotalcite for a safe skin photoprotection.
Methods
The intercalation products were prepared incubating hydrotalcite (HTlc) in aqueous solutions of FERH sodium salt at different temperatures over 4 and 8 days. Quantitative determination of intercalated FERH was performed by thermogravimetric analysis and morphology by scanning electron microscopy (SEM). FERH stability study was carried out at different pHs and temperatures. FERH was analyzed by reversed phase–high-performance liquid chromatography. Response surface methods (RSMs) were used to assess optimal intercalation conditions and FERH stability.
Results
In all intercalation products, FERH content was found to be about 48% w/w except when the intercalation process was carried out at 52°C for 8 days and at 60°C for both 4 and 8 days, which resulted to be 40.39, 39.99, and 34.99%, respectively. The RSM designs showed that intercalation improvement can be achieved by working at pH 6, at temperatures below 40°C, and over 4 days of incubation.
Conclusions
The optimal conditions for a proper FERH intercalation were assessed. The development of a new optimized protocol may improve HTlc–FER complex performances and safety by augmenting dosage and reducing the presence of harmful reactive species in the final formulation.
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Acknowledgments
This work was supported by the Italian Ministry for Education, University and Research (MIUR)—research programs of national interest.
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Schoubben, A., Blasi, P., Giovagnoli, S. et al. Evaluation and Optimization of the Conditions for an Improved Ferulic Acid Intercalation into a Synthetic Lamellar Anionic Clay. Pharm Res 23, 604–613 (2006). https://doi.org/10.1007/s11095-005-9394-y
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DOI: https://doi.org/10.1007/s11095-005-9394-y