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A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer

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Pharmaceutical Chemistry Journal Aims and scope

Triple-negative breast cancer (TNBC) accounts for 15 – 20% of all other types of cancer. Due to the lack of target-specific compounds against particular targets and resistance in TNBC therapy, there is a need for the development of effective therapy against TNBC. Using a natural product in chemoprevention is beneficial because of fewer side effects and low toxicity profile compared to compounds of synthetic origin. In the present review, we summarize natural products with chemopreventive activities against TNBC cell lines. In addition, we also covered targets of TNBC and conventional therapy used for treating TNBC with their mechanism of action. The present review may provide useful information on compounds for TNBC prevention.

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Acknowledgments

We would like to thank Dr. H. N. More, Principal, Bharati Vidyapeeth College of Pharmacy for providing the necessary laboratory facilities.

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  1. Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416013, India

    Aarti A. Varne, Manish S. Bhatia & Snehal S. Ashtek

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Varne, A.A., Bhatia, M.S. & Ashtek, S.S. A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer. Pharm Chem J 57, 694–702 (2023). https://doi.org/10.1007/s11094-023-02940-y

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