Microbial resistance to antibiotics is a serious challenge for both medicine and veterinary. Several mechanisms of antibiotic resistance development are known. Although, there are some approaches to overcome this threat, no final solution has been found yet. In this context, herbal preparations are of great interest due to their high therapeutic value, synergistic abilities with known antibiotics, and few side effects. Literature data suggest a number of plant species with antimicrobial properties against pathogenic, non-pathogenic, antibiotic-susceptible and resistant microbial strains. The present review considers literature data published within the last ten years concerning the most studied plant species of Lamiaceae family, possessing remarkable antimicrobial activity.
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S. C. Lourenço, M. Moldão-Martins, and V. D. Alves, Molecules, 24(22), 4132 (2019).
M. Laxa, M. Liebthal, W. Telman, et al., Antioxidants, 8(4), 94 (2019).
S. Wang, S. Alseekh, A. R. Fernie, and J. Luo, Mol. Plant., 12, 899 – 919 (2019).
P. D. Gupta and T. J. Birdi, J. Ayurveda Integr. Med., 8(4), 266 – 275 (2017).
G. Nieto, Plants (Basel), 30 9(8):961 (2020).
N. Sahakyan, A. Bartoszek, C. Jacob, et al., Curr. Pharmacol. Rep., 6, 131 – 136 (2020).
I. L. Elisha, F. S. Botha, L. J. McGaw, and J. N. Eloff, BMC Complem. Altern.. Med., 17(1), 133 (2017).
C. L. Gorlenko, H. Y. Kiselev, E. V. Budanova, et al., Antibiotics, 9(4), 170 (2020).
N. Sahakyan, M. Petrosyan, and A. Trchounian, Curr. Pharm. Des., 25(16), 1861 – 1865 (2019).
G. Yuan, Y. Guan, H. Yi, et al., Sci.Rep. 11, 10471 (2021).
F. Chassagne, T. Samarakoon, G. Porras, et al., Front. Pharmacol., 11, 586548 (2021).
N. Jubair, M. Rajagopal, S. Chinnappan, et al., Evid. Based Complem. Altern. Med., 2021, Article ID 3663315 (2021).
S. E. Boyd, D. M. Livermore, D. C. Hooper, and W. W. Hope, Antimicrob. Agents Chemother., 64, e00397-20 https: // doi.org / 10.1128 / AAC.00397-20 (2020).
M. J. Cheesman, A. Ilanko, B. Blonk, and I. E. Cock, Pharmacogn. Rev., 11(22), 57 – 72 (2017).
M. Ginovyan and A. Trchounian, Proc. Yerevan State Univ. Chem. Biol., 51(1), 44 – 53 (2017).
N. Sahakyan, M. Petrosyan, and A. Trchounian, Int. J. Biol. Biomol. Agric. Food. Biotechnol., Eng. 10, 322 – 326 (2016).
A. Avetisyan, A. Markosian, M. Petrosyan, et al., BMC Complem. Altern. Med., 17, 60 (2017).
A. Moghrovyan, N. Sahakyan, A. Babayan, et al., Curr. Pharm. Des., 25: 1809. 2019ID 3663315 (2021).
N. Zh. Sahakyan, M. T. Petrosyan and A. H. Trchounian, Proc. Yerevan State Univ. Chem. Biol., 53(1), 23 – 28 (2019).
B. Khameneh, M. Iranshahy, V. Soheili, and B. S. Fazly Bazzaz, Antimicrob. Resist. Infect. Control., 16(8), 118 (2019).
Y. Su, D. Wu, H. Xia, et al., Environ. Int., 128, 407 – 416 (2019).
S. Hambardzumyan, N. Sahakyan, M. Petrosyanet, et al., AMB Expr., 10, 162 (2020).
S. Gevorgyan, R. Schubert, M. Yeranosyan, et al., AMB Expr., 11, 51 (2021).
Z. Ferdous and A.Nemmar, Int. J. Mol. Sci., 21(7), 2375. (2020).
R. A. Hussein and A. A. El-Anssary, Plant Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants, in: Herbal Medicine, Philip F. Builders, Intech Open, DOI: 10.5772 / intechopen.76139 (2018).
J. Kurek (November 13th 2019). Introductory Chapter: Alkaloids – Their Importance in Nature and for Human Life, Alkaloids – Their Importance in Nature and Human Life, Joanna Kurek, IntechOpen, DOI: 10.5772 / intechopen.85400. Available from: www.intechopen.com/chapters/66742
M. Nakayasu, S. Yamazaki, Y. Aoki, et al., Plants, 10, 2189 (2021).
H. Cory, S. Passarelli, J. Szeto, et al., Front. Nutr., 21, 5:87 (2018).
K. V. Bezmaternykh, T. I. Shirshova, I. V. Beshley, et al., Pharm. Chem. J., 48(2), 116 – 120 (2014).
S.-Y. Teow, K. Liew, S. A. Ali, et al., J. Trop. Med., 2016, Article ID 2853045 (2016).
I. Camele, H. S. Elshafie, L. Caputo and V. De Feo, Front. Microbiol., 10: 2619 (2019).
M. Ginovyan, N. Sahakyan, M. Petrosyan and A. Trchounian, Proc. of the Yerevan State Univ. Chemistry and Biology, 55 (1-254), 25 – 38 (2021).
J. A. Imlay, Environ. Microbiol. 21(2), 521 – 530 (2019).
A. J. Seukep, V. Kuete, L. Nahar, et al., J. Pharm. Anal., 10(4), 277 – 290 (2020).
A. Domenech, A. R. Brochado, V. Senderet al., Cell Host Microbe, 27(4), 544 – 555 (2020).
R. Subramani, M. Narayanasamy and K. D. Feussner, 3Biotech. 7(3), 172 (2017).
C. M. Uritu, C. T. Mihai, G. D. Stanciu, et al., Pain Res. Manag., 2018, 7801543 (2018).
I. Cocan, E. Alexa, C. Danciu,, et al., Exp. Ther. Med., 15(2), 1863 – 1870 (2018).
A. Escobar, M. Pérez, G. Romanelli, et al., Arabian J. Chem., 13(12), 9243 – 9269 (2020).
N. Sahakyan, M. Petrosyan, I. Koss-Miko3ajczyk, et al., Free Rad. Res., 53(sup1), 1153 – 1162 (2019).
C. Uritu, C. T. Mihai, G. D. Stanciu, et al., Pain Res. Manag., 2018, Article ID 7801543, 44 pages, (2018).
R. M. Harley, S. Atkins, A. L. Budantsev,, et al., 2004. “Labiatae” pages 167 – 275. In: Klaus Kubitzki (Editor) and Joachim W. Kadereit (Volume Editor). The Families and Genera of Vascular Plants, volume VII. Springer-Verlag, Berlin – Heidelberg, Germany. ISBN 978-3-540-40593-1
M. H. Shahrajabian, W. Sun, Q. Cheng, Int. J. Food Prop., 23(1) 1961 – 1970, (2020).
V. Kumar, T. Markoviæ, M. Emerald, et al., Encyclopedia of Food and Health, (2016), pp. 332 – 337.
T. Tangpao, H-H. Chung, S. R. Sommano Aromatic Profiles of Essential Oils from Five Commonly Used Thai Basils. Foods, 2018; 7(11):175 (2018).
C. Majdi, C. Pereira, M. I. Dias, et al., Antioxidants (Basel), 29, 9(5):369 (2020)
A. Wesolowska and D. Jadczak, Not Bot Horti Agrobot Cluj Napoca, 47(3), 829 – 835 (2019).
M. K. Swamy, M. S. Akhtar and U. R. Sinniah, Evid.-Based Complem. Altern. Med., 2016, Article ID 3012462, 21 pages (2016).
A. Puškárová, M. Buèková, L. Kraková, et al., Sci. Rep., 7, 8211 (2017).
Q. Benameur, T. Gervasi, V. Pellizzeri, et al., Nat. Prod. Res., 33(18), 2647 – 2654 (2019).
L. Galovièová, P. Borotová, V. Valková, et al. Plants, 10(7), 1416. (2021).
D. Salaria, R. Rolta, C. N. Patel, J. Biomol. Struct. Dyn., 8, 1 – 20 (2021).
S. Ivasenko, P. Orazbayeva, K. Skalicka–Wozniak, et al., Maced J. Med. Sci., 9(A), 61 – 67 (2021).
W. Ouedrhiri, B. Mounyr, E. H. Harki, et al., Int. J. Food Prop., 20(12), 3149 – 3158 (2017).
T. Yin, L. Cai, Zh. RSC Advances, 10, 35072 – 35089 (2020).
V. Rodrigues, C. Cabral, L. Évora, et al., Arab. J. Chem., 12, 3236 – 3243 (2019).
F. Ben Abdallah, R. Lagha and A. Gaber, Pharmaceuticals, 13(11), 369 (2020).
C. Ballester-Costa, E. Sendra, J. Fernández-López, et al., Foods, 28, 6(8):59 (2017).
F. Z. Sadiki, M. El Idrissi and M. Sbiti, Spec. J. Med. Res. Health Sci., 4(3), 59 – 64 (2019).
I. Oniga, C. Puscas, R. Silaghi-Dumitrescu, et al., Molecules, 23(8), 2077 (2018).
M. Lu, T. Dai, C. K. Murray, et al., Front. Microbiol., 9, 2329 (2018).
I. El-Alam, R. Zgheib, M. Iriti, et al., Foods, 8(3), 90 (2019).
R. A. Alwafa, S. Mudalal, and G. Mauriello, Plants, 10, 1001 (2021).
T. Esposito, F. Sansone, G. Auriemma, Pharmaceutics, 12(7), 671 (2020).
X. Qing, H.-M. Yan, Z.-Y. Ni, et al., Heterocycl. Commun., 23(4), 245 – 268 (2017).
M. Alreshidi, E. Noumi, L. Bouslama, et al., Plants, 9(11), 1418(2020).
Y. El Atki, I. Aouam, F. Kamari, et al., Arab. J. Chem., 13(2), 3866 – 3874 (2020).
M. Safavi, R. Sabourian and A. Foroumadi, World J. Clin. Cases, 16, 4(1)5– 19 (2016).
B. S. Thawkar, A. G. Jawarkar, P. V. Kamalkar, Int. J. Green Pharm., 10, 71 – 76 (2016).
M. J. Nirmala, L. Durai, G. S. Anusha, et al., BioNanoSci, 11, 1017 – 1029 (2021).
F. Brahmi, M. Khodir, C. Mohamed, et al., 2017 Chemical Composition and Biological Activities of Mentha Species, Aromatic and Medicinal Plants – Back to Nature, Hany A. El-Shemy, IntecOpen, doi: https://doi.org/10.5772/67291
A. A. Taherpour, S. Khaef, A. Yari, et al., J. Anal. Sci. Technol., 8, 11 (2017).
M. H. F. Shalayel, A. M. Asaad, M. A. Qureshi, et al., J. Herb. Med., 7(2017), 27 – 30 (2017).
S. Angeloni, E. Spinozzi, F. Maggi, et al., Plants, 10, 195 (2021).
O. Koshovyi, A. Raal, I. Kireyev, et al., Plants, 10, 230 (2021).
Y. Romanenko, O. Koshovyi, T. Ilyina, et al., ScienceRise. Pharm. Sci., 1(17), 17 – 23 (2019).
J. R. de Oliveira, S. E. A. Camargo, and L. D. de Oliveira, J. Biomed. Sci., 26, 5 (2019).
S. Habtemariam, Evid. Based Complem. Altern. Med., 2016, 2680409. (2016).
G. Nieto, G. Ros and J. Castillo, Medicines (Basel), 4(3), 98 (2018).
J. Stojiljkovic, M. Trajchev, D. Nakov, et al., Adv. Cytol. Pathol., 3(4), 93 – 96 (2018).
R. Sabbobeh, H. Hejaz, A. Jahajha, et al., J. Appl. Pharm. Sci., 6(01), 076 – 082 (2016).
Y. Ezzoubi, D. Bousta and A. A. Farah, Clin. Phytosci., 6, 9 (2020).
F. Baali, S. Boumerfeg, E. Napoli, et al., J. Essent. Oil-Bear. Plants, 22(3), 821 – 837 (2019).
S. de Rapper, A. Viljoen and S. van Vuuren, Evid.-Based Complem. Altern. Med., Article ID 2752739 (2016).
D. Predoi, S. L. Iconaru, N. Buton, et al., Nanomaterials (Basel), 8(5):291 (2018).
W. H. Leong, K. S. Lai, and S. H. E. Lim, Processes, 9(4), 609 (2021).
D. J. Newman, J. Med. Chem., 51, 2589 – 2599 (2008).
S. Andrei, G. Droc, G. Stefan, FDA approved antibacterial drugs: 2018 – 2019 Discoveries (Craiova), Dec 31, 7(4), e102 (2019).
2020 Antibacterial agents in clinical and preclinical development: an overview and analysis. Geneva: World Health Organization (2021).
B. M. Lawrence, A further examination of the variation of Ocimum basilicum, in: B. M. Lawrence, B. D. Mookerjee, and B. J. Willis (Eds.), Flavors and Fragrances: A World Perspective, Amsterdam: Elsevier Sci. Publ. B. V (1988), pp. 161 – 170.
G. Tsasi, T. Mailis, A. Daskalaki, et al., Plants, 6(3), 41 (2017).
B. Salehi, M. Abu-Darwish, A. H. Tarawneh, et al., Trends Food Sci. Technol., 85, 287 – 306 (2019).
Z. Akan, M. Dikilidal, H. Ozdemir, et al., Med. Sci. Discov., 1(2), 51 – 60 (2019).
A. S. P. Pereira, A. J. Banegas-Luna, J. Peña-García, et al., Molecules, 24(22), 4030 (2019).
J. Rahmawati, D. Muhammad, A. S. Wahyuni, et al., EurAsian J. BioSci., 14, 5341 – 5346 (2020).
T. Haile, S. M. Cardoso, C. de Oliveira Raphaelli, et al., Front. Pharmacol., 12, 621536 (2021).
M. A. Picos-Salas, J. B. Heredia, N. Leyva-López, et al., Processes, 9(9),1675 (2021).
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Sahakyan, N.Z. Lamiaceae Family Plants: One of the Potentially Richest Sources of Antimicrobials. Pharm Chem J 57, 565–572 (2023). https://doi.org/10.1007/s11094-023-02921-1
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DOI: https://doi.org/10.1007/s11094-023-02921-1