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Supramolecular Complex of Lappaconitine Hydrobromide and the Monoammonium Salt of Glycyrrhizic Acid: Synthesis, Physicochemical Characteristics, and Antiarrhythmic Activity

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Pharmaceutical Chemistry Journal Aims and scope

The aim of the work was to create new dosage forms of lappaconitine hydrobromide characterized by a modified mechanism and nature of drug release and to study their specific activity on in vitro arrhythmia models in the papillary muscle of rat heart in comparison to the currently used drug Allapinin® (lappaconitine hydrobromide). Complexes of lappaconitine hydrobromide with the monoammonium salt of glycyrrhizic acid (MASGA) in molar ratios of 1/2 and 1/4 were synthesized. The physicochemical characteristics of the obtained complexes were determined. Their biological activity was studied in comparison to Allapinin® with aconitine-induced arrhythmia in rats. The contractile activity of the papillary muscle disturbed by aconitine was restored by the 1/4 complex compound of lappaconitine hydrobromide with MASGA within 8 min after its introduction into the medium while a similar effect of the 1/2 complex and Allapinin® was observed after 10 and 15 min, respectively. Moreover, the restored contractile activity of the papillary muscle in the presence of the 1/4 complex was retained longer (130 min) as compared to Allapinin® (90 min). The obtained complex could be used to create a prolonged-action antiarrhythmic drug with improved properties.

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References

  1. O. Z. Yasin, V. R. Vaidya, et al., J. Innov. Card. Rhythm Manag., 9(7), 3239 – 3243 (2018).

    Article  Google Scholar 

  2. S. F. Sokolov, S. A. Bakalov, et al., Kardiologiya, No. 1, 20 – 26 (2014).

  3. RF Government Order No. 2406-r of Oct. 12, 2019.

  4. S. F. Sokolov and F. N. Dzhakhangirov, Kardiologiya, No. 7, 96 – 102 (2002).

  5. S. F. Sokolov, M. M. Belyaeva, et al., Kardiologiya, No. 4, 45 – 52 (2017).

  6. F. N. Dzhakhangirov and S. F. Sokolov, New Antiarrhythmic Drug Allapinin (Pharmacology and Clinical Application) [in Russian], Tashkent (2004).

  7. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (1996); http: // www.lawmix.ru / abro.php?id=11036.

  8. L. Rozenshtraukh, Fiziol. Zh. SSSR, 51, No. 9, 1071 – 1080 (1965).

    Google Scholar 

  9. M. M. Musaev, P. B. Usmanov, et al., Computer Program “Analysis of the Kinetics of Muscle Contraction”: State Patent Office of the RUz Certificate No. DGU 01873, Dec. 18, 2009; Off. Bull., 1(9), 170 – 171.

  10. G. A. Tolstikov, Khim.-farm. Zh., 30(5), 36 – 38 (1996).

    CAS  Google Scholar 

  11. G. A. Tolstikov, A. A. Baltina, et al., Licorice. Biodiversity, Chemistry, and Use in Medicine [in Russian], Akad. Izd. GEO, Novosibirsk (2007), pp. 260 – 272.

  12. G. A. Tolstikov, L. A. Baltina, et al., Bioorg. Khim., 23(9), 691 – 709 (2007).

    Google Scholar 

  13. Q. Zhang, N. E. Polyakov, et al., Drug Delivery, 25, 198 – 209 (2018).

    Article  Google Scholar 

  14. G. A. Tolstikov, E. E. Shul’ts, et al., Khim. Interesakh Ustoich. Razvit., 5(1), 57 – 73 (1997).

  15. T. G. Tolstikova, A. G. Tolstikov, et al., Vestn. Ross. Akad. Nauk, 77(10), 867 – 874 (2007).

    CAS  Google Scholar 

  16. A. O. Bryzgalov, T. T. Tolstikova, et al., Eksp. Klin. Farmakol., 68(4), 24 – 27 (2005).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. A. A. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, 83 Mirzo-Ulugbeka St, Tashkent, Uzbekistan, 100125

    Zh. F. Ziyavitdinov, U. Zh. Ishimov, N. Sh. Berdiev, Yu. I. Oshchepkova & Sh. I. Salikhov

  2. Institute of Biophysics and Biochemistry, National University of Uzbekistan, 174 Talabalar St, Tashkent, Uzbekistan, 100125

    I. Z. Zhumaev & P. B. Usmanov

Authors
  1. Zh. F. Ziyavitdinov
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  2. U. Zh. Ishimov
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  3. N. Sh. Berdiev
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  4. I. Z. Zhumaev
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  5. Yu. I. Oshchepkova
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  6. P. B. Usmanov
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  7. Sh. I. Salikhov
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Corresponding author

Correspondence to Yu. I. Oshchepkova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 2, pp. 25 – 32, February, 2022.

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Ziyavitdinov, Z.F., Ishimov, U.Z., Berdiev, N.S. et al. Supramolecular Complex of Lappaconitine Hydrobromide and the Monoammonium Salt of Glycyrrhizic Acid: Synthesis, Physicochemical Characteristics, and Antiarrhythmic Activity. Pharm Chem J 56, 167–173 (2022). https://doi.org/10.1007/s11094-022-02618-x

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  • DOI: https://doi.org/10.1007/s11094-022-02618-x

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