A new optimal synthetic scheme for new antibacterial compounds combining tris-(1-alkyindol-3-yl)methylium and 3-(indol-1-yl)maleimide in their structures was developed. The proposed method provided a significant increase in the product yield, reduced the labor intensiveness and number of steps, and used readily accessible starting reagents. Agood yield was achieved for 3-(formylindol-1-yl)-4-chloromaleimide, a universal precursor enabling two-step syntheses of target tri(indolyl)methanes and production of an extensive library of analogous potentially active compounds from other 1-alkylindoles and various amines and thiols.
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Thee work was supported by a Russian Science Foundation Grant (Project No. 16 – 15 – 10300P).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 12, pp. 33 – 38, December, 2020.
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Simonov, A.Y., Panov, A.A., Trenin, A.S. et al. Optimization of the Synthesis of New Antibacterial Compounds with Tris(1-Alkylindol-3-YL)Methylium Fragments. Pharm Chem J 54, 1263–1268 (2021). https://doi.org/10.1007/s11094-021-02352-w
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DOI: https://doi.org/10.1007/s11094-021-02352-w