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Cytotoxic Effect of Palladium(II) Complex with 4-Amino-5-Methyl-2H-1,2,4-Triazole-3(4H)-Thione Ligand on MCF-7 Cell Line

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Pharmaceutical Chemistry Journal Aims and scope

Cytotoxic effect of a palladium(II) complex, [Pd(AMTT)2]Cl2 2H2O (AMTT = 4-amino-5-methyl-2H-1,2,4-triazole-3(4H)-thione), on MCF-7 cell line has been investigated. The cytotoxicity of Pd(II) complex was assessed in vitro by the MTT assay performed on MCF-7 human breast cancer cell line. The influence of complex concentration on cell viability has been studied and expressed as half maximum inhibitory concentration (IC50) values after 48 h incubation. For [Pd(AMTT)2]Cl2 2H2O complex on MCF-7 cell line this value is 0.925 mM.

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Acknowledgments

The authors are grateful to Yazd Branch of the Islamic Azad University for the support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran

    Elham Sajadiyeh & Masoumeh Tabatabaee

  2. Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran

    Sayed Morteza Seifati

  3. Department of Chemistry, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran

    Zohreh Derikvand

Authors
  1. Elham Sajadiyeh
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  2. Masoumeh Tabatabaee
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  3. Sayed Morteza Seifati
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  4. Zohreh Derikvand
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Correspondence to Masoumeh Tabatabaee.

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Sajadiyeh, E., Tabatabaee, M., Seifati, S.M. et al. Cytotoxic Effect of Palladium(II) Complex with 4-Amino-5-Methyl-2H-1,2,4-Triazole-3(4H)-Thione Ligand on MCF-7 Cell Line. Pharm Chem J 54, 145–147 (2020). https://doi.org/10.1007/s11094-020-02171-5

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  • DOI: https://doi.org/10.1007/s11094-020-02171-5

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