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Antioxidant Activity of Ruthenium(Ii) Complexes Containing Tridentate Triamines and Their Capability to Inhibit Xanthine Oxidase

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Pharmaceutical Chemistry Journal Aims and scope

Biological activities of organoruthenium complexes [chloro [N,N′-[(2,6-pyridinediyl-κN) diethylidyne] bis-[benzenamine-κN]] [N-[(2-pyridinyl-κN) methylene] benzenesulfonamide-κN] ruthenium(II)] chloride (Cmplx 1), [chloro [2,2′-(2,6-pyridinediyl-κN) bis [1H-benzimidazole-κN3]][N-[(2-pyridinyl-κN) methylene] benzenesulfonamide-κN] ruthenium(II)] chloride (Cmplx 2), and [chloro[2,6-di(1H-pyrazol-3-yl-κN2) pyridine-κN] [N-[(2-pyridinyl-κN) methylene] [benzenesulfonamide-κN] ruthenium(II)] chloride (Cmplx 3) have been studies. The compounds were tested for in vitro biological activity on test models including 2,2-diphenyl-1-picryl-hydrazyl (DPPH) reducing power, superoxide anion radical-scavenging activity, and lipid peroxidation activity by ferric thiocyanate. It is established that Cmplx 2 with benzimidazole ligand displays significant xanthine oxidase inhibitory activity (IC50 = 53.80 ± 2.69 μM), DPPH free radical scavenging activity (79.49 ± 1.59), and superoxide anion radical scavenging activity (75.73 ± 2.85%). The coordination of benzenamine and benzenesulfanoamine ligands reduces lipid peroxidation as observed in the case of Cmplx 1 (87.17 ± 3.88%) and the higher reducing power of Cmplx 1 obtained at all concentrations. It was concluded from the test results that organoruthenium complexes showed much better antioxidant activity than expected.

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Acknowledgements

The authors thank for financial support the Scientific and Technological Research Council of Turkey (TÜBÝTAK; 111T560) and the Scientific Research Project Department of Bingol University (BÜBAP; 2010 – 07)

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Authors and Affiliations

  1. Laboratory of Natural Product Research, Department of Occupational Health and Safety, Faculty of Health Sciences, Bingol University, 12000, Bingol, Turkey

    Ýbrahim H. Gecibesler, Osman Dayan, Zafer Şerbetçi & İbrahim Demirtas

  2. Laboratory of Inorganic Synthesis and Molecular Catalysis, Department of Chemistry, Faculty of Science and Art, Çanakkale Onsekiz Mart University, 17020, Çanakkale, Turkey

    Ýbrahim H. Gecibesler, Osman Dayan, Zafer Şerbetçi & İbrahim Demirtas

  3. Department of Chemistry, Faculty of Science, Cankýrý Karatekin University, 18200, Cankýrý, Turkey

    Ýbrahim H. Gecibesler, Osman Dayan, Zafer Şerbetçi & İbrahim Demirtas

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  1. Ýbrahim H. Gecibesler
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Correspondence to Ýbrahim H. Gecibesler.

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Gecibesler, Ý.H., Dayan, O., Şerbetçi, Z. et al. Antioxidant Activity of Ruthenium(Ii) Complexes Containing Tridentate Triamines and Their Capability to Inhibit Xanthine Oxidase. Pharm Chem J 53, 914–920 (2020). https://doi.org/10.1007/s11094-020-02099-w

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  • DOI: https://doi.org/10.1007/s11094-020-02099-w

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