[3,3-Dialkyl-3,4-dihydroisoqinolin-1(2H)-ylidene]-N-alkylacetamides were synthesized by reacting dialkylbenzylcarbinols with N-alkylcyanoacetamides. Hydrochlorides of the synthesized compounds existed in the imine form. All hydrochlorides showed antiarrhythmic and coagulant (hemostatic) effects. An amide with an unsubstituted amide N atom and a 3-spiro-cyclopentyl moiety was the most active compound with antiarrhythmic activity 2.8 times that of lidocaine and blood coagulation accelerated by 37.9%, which was 21.9% faster than etamsylate.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 6, pp. 24 – 27, June, 2019.
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Gashkova, O.V., Mikhailovskii, A.G., Rudakova, I.P. et al. Synthesis and Antiarrhythmic and Hemostatic Activity of [3,3-Dialkyl-3, 4-Dihydroisoquinolin-1(2H )-Ylidene]-N-Alkylacetamides. Pharm Chem J 53, 507–510 (2019). https://doi.org/10.1007/s11094-019-02028-6
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DOI: https://doi.org/10.1007/s11094-019-02028-6