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Antimicrobial Activity of Dioxidine Against Strains of Potential Pathogens of Otorhinolarygological Infections

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We present here the results of our studies of the in vitro antibacterial and antifungal activity of dioxidine (hydroxymethylquinoxaline dioxide) against 32 strains of bacteria and fungi. Dioxidine was found to exhibit high levels of activity against two of the anaerobic bacteria tested: Peptostreptococcus anaerobius and Bacillus fragilis (MIC ≤ 0.125 μg/ml). Dioxidine was moderately active against Gram-negative bacteria (MIC 8 – 64 μg/ml) apart from Pseudomonas aeruginosa (MIC = 1024 μg/ml) and Stenotrophomonas maltophila (MIC = 512 μg/ml). Dioxidine inhibited the growth of Gram-positive bacteria but at higher concentrations than for Gram-negative bacteria (MIC 64 – 1024 μg/ml). Dioxidine at 1024 μg/ml delayed the growth of yeast-like fungi of the genus Candida (C. albicans). The mold fungus Aspergillus niger was resistant to dioxidine (MIC > 4096 μg/ml).

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Authors and Affiliations

  1. Not-for-profit Cooperative Healthcare Partnership Scientific Center for Quality Control, 3 Second Roshchinskaya Street, 115191, Moscow, Russia

    T. A. Gus’kova

  2. V. V. Zakusov Science Research Institute of Pharmacology, 8 Baltiiskaya Street, 125315, Moscow, Russia

    A. D. Durnev

  3. I. M. Sechenov First Moscow State Medical University, Building 2, 8 Trubetskaya Street, 119991, Moscow, Russia

    D. V. Reikhart

  4. OAO Valent Pharm, Building 2, 18 General Dorokhov Street, 119530, Moscow, Russia

    A. P. Chernyavtseva

Authors
  1. T. A. Gus’kova
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  2. A. D. Durnev
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  3. D. V. Reikhart
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  4. A. P. Chernyavtseva
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Corresponding author

Correspondence to T. A. Gus’kova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 7, pp. 35 – 39, July, 2016.

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Gus’kova, T.A., Durnev, A.D., Reikhart, D.V. et al. Antimicrobial Activity of Dioxidine Against Strains of Potential Pathogens of Otorhinolarygological Infections. Pharm Chem J 50, 465–470 (2016). https://doi.org/10.1007/s11094-016-1470-6

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  • DOI: https://doi.org/10.1007/s11094-016-1470-6

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