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Peptide Derivatives of 1,2-Dihydro-3-Methyl-2-Oxoquinoxaline-6-Carboxylic Acid: Synthesis and Evaluation of Antimicrobial, Antifungal and Antiviral Potential

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Pharmaceutical Chemistry Journal Aims and scope

1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid (S1) was prepared and coupled with various amino acid tri/tetrapeptide methyl esters to afford new quinoxalopeptide derivatives (S1a – S1i). The synthesized derivatives were characterized and screened for their antibacterial, antifungal and anthelmintic activity. Furthermore, molecular docking study revealed their potential in targeting human papillomavirus (HPV-16) E6 oncoprotein.

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Authors and Affiliations

  1. College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates

    Sachin Chaudhary & Hamadeh Tarazi

  2. School of Pharmaceutical Sciences, IFTM University, Lodhipur rajpoot, Delhi road, Moradabad, 244001, Uttar Pradesh, India

    Sachin Chaudhary & Sushil Kumar

Authors
  1. Sachin Chaudhary
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  2. Sushil Kumar
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  3. Hamadeh Tarazi
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Correspondence to Sachin Chaudhary.

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Chaudhary, S., Kumar, S. & Tarazi, H. Peptide Derivatives of 1,2-Dihydro-3-Methyl-2-Oxoquinoxaline-6-Carboxylic Acid: Synthesis and Evaluation of Antimicrobial, Antifungal and Antiviral Potential. Pharm Chem J 50, 331–338 (2016). https://doi.org/10.1007/s11094-016-1447-5

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  • DOI: https://doi.org/10.1007/s11094-016-1447-5

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