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Synthesis and Cytotoxic Activity of 1,2,3-Triazole Derivatives in Glioma Cell Cultures

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Pharmaceutical Chemistry Journal Aims and scope

A series of 1,2,3-triazole derivatives was prepared and their cytotoxic actions on glioma cell cultures were studied. Amethod for the synthesis of 1-R-5-methyl-1 H-[1,2,3]triazole-4-carboxamides is presented, based on transformation of 4-acetyl-1-phenyl-1 H-[1,2,3]-triazolate sodium using primary amine hydrochlorides.

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Authors and Affiliations

  1. First President of Russia B. N. El’tsin Urals Federal University, Ekaterinburg, Russia

    I. S. Khazhieva, T. V. Glukhareva, O. S. El’tsov, Yu. Yu. Morzherin, A. A. Minin, V. A. Pozdina & M. V. Ulitko

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  1. I. S. Khazhieva
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  2. T. V. Glukhareva
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  3. O. S. El’tsov
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  4. Yu. Yu. Morzherin
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  5. A. A. Minin
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  6. V. A. Pozdina
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  7. M. V. Ulitko
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 5, pp. 12 – 15, May, 2015.

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Khazhieva, I.S., Glukhareva, T.V., El’tsov, O.S. et al. Synthesis and Cytotoxic Activity of 1,2,3-Triazole Derivatives in Glioma Cell Cultures. Pharm Chem J 49, 296–300 (2015). https://doi.org/10.1007/s11094-015-1273-1

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  • DOI: https://doi.org/10.1007/s11094-015-1273-1

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