Series of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides were synthesized in good yields via the reaction of N-arylacetoacetamides and aromatic aldehydes in EtOH in the presence of piperidine. The synthesized compounds were tested for antimicrobial activity.
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V. L. Gein, E. B. Levandovskaya, N. V. Nosova, et al., Zh. Org.Khim., 43(7), 1101 – 1102 (2007).
V. L. Gein, E. B. Levandovskaya, N. V. Nosova, et al., Khim.-farm. Zh., 41(12), 21 – 23 (2007); Pharm. Chem. J.,41(12), 643 – 645 (2007).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 4, pp. 36 – 38, April, 2015.
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Gein, V.L., Odegova, T.F., Yankin, A.N. et al. Synthesis and Antimicrobial Activity of N,N′,2-Triaryl-6-Hydroxy-6-Methyl-4-Oxocyclohexane-1,3-Dicarboxamides. Pharm Chem J 49, 246–249 (2015). https://doi.org/10.1007/s11094-015-1264-2
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DOI: https://doi.org/10.1007/s11094-015-1264-2