Skip to main content
SpringerLink
Log in

Synthesis and neurotropic activity of new derivatives of piperazino-substituted pyrano[3,4-c]pyridines

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Methods for the synthesis of new derivatives of substituted piperazines were developed. Syntheses were based on chloro derivatives of pyrano[3,4-c]pyridines. The anticonvulsive and predicted tranquillizer activities of the compounds synthesized here were studied. Compounds with neurotropic – anticonvulsive, antiamnestic, and sedative – properties were identified.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. D. Mashkovskii, Medicines [in Russian], Novaya Volna, Moscow (2000), Vol. 1, pp. 252, 280; Vol. 2, pp. 294–295.

  2. E. Carcellar, M. Merlos, M. Giral, et al., J. Med. Chem., 36, 2984 (1993).

    Article  Google Scholar 

  3. S. N. Sirakanyan, E. G. Paronikyan, M. S. Gukasyan, and A. S. Noravyan, Arm. Khim. Zh., 62(3–4), (2009).

  4. E. G. Paronikyan, S. N. Sirakanyan, A. S. Noravyan, et al., Arm. Khim. Zh., 43(8), 518 (1990).

    CAS  Google Scholar 

  5. E. G. Paronikyan, S. N. Sirakanyan, A. S. Noravyan, et al., Khim.-Farm. Zh., 35(1), 9–12 (2001).

    Google Scholar 

  6. Drug Discovery and Evaluation. Pharmacological Agents, H. G. Vogel and W. H. Vogel (eds.), Springer, Berlin and New York (1997), pp. 246–350.

  7. A. P. Mkrtchyan, S. G. Kazaryan, A. S. Noravyan, et al., Khim.-Farm. Zh., 32(9), 15–19 (1998).

    CAS  Google Scholar 

  8. I. A. Dzhagatspanyan and A. B. Asryan, Éksperim. Klin. Farmakol., No. 1, 5–8 (1994).

  9. G. Dawson and M. D. Tricklebank, Trends Pharmacol., 16, 33–36 (1995).

    Article  CAS  Google Scholar 

  10. S. E. File, Behav. Brain Res., 58, 199–202 (1993).

    Article  PubMed  CAS  Google Scholar 

  11. A. Covanis, A. Gupta, and P. Jeavons, Epilepsia, 23, 693–720 (1982).

    Article  PubMed  CAS  Google Scholar 

  12. T. Ketter, R. Post, and W. Theodore, Neurology, 53, No. 2, 53–67 (1999).

    Google Scholar 

  13. J. Buresh and O. Bureshova, J. Comp. Physiol. Psychol., 756, 286–272 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences, Yerevan, Republic of Armenia

    S. N. Sirakanyan, A. S. Noravyan, I. A. Dzhagatspanyan, I. M. Nazaryan, A. A. Ovakimyan, A. G. Akopyan & N. G. Avetisyan

Authors
  1. S. N. Sirakanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. S. Noravyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. A. Dzhagatspanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. M. Nazaryan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. A. Ovakimyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. G. Akopyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. G. Avetisyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 10, pp. 14–17, October, 2012.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sirakanyan, S.N., Noravyan, A.S., Dzhagatspanyan, I.A. et al. Synthesis and neurotropic activity of new derivatives of piperazino-substituted pyrano[3,4-c]pyridines. Pharm Chem J 46, 591–594 (2013). https://doi.org/10.1007/s11094-013-0852-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-013-0852-2

Keywords

Search

Navigation