A series of new pyranochromen-3-carboxamides have been synthesized in good yield by reacting 2-phenyl-4-hydroxy-6H-1,3-thiazin-6-ones with substituted 3-formylchromones. Pharmacological screening showed an influence of the substituent in the 9-position of the pyranochromen-3-carboxamides on the acute toxicity and antifungal, analgesic, and anxiolytic activity. 9-Bromo-2H,5H-pyranochromen-3-carboxamide can be recommended for further pharmacological investigation.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 1, pp. 12 – 17, January, 2012.
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Shutov, R.V., Kuklina, E.V., Anisimova, N.A. et al. Synthesis and biological activity of new pyranochromen-3-carboxamides. Pharm Chem J 46, 10–14 (2012). https://doi.org/10.1007/s11094-012-0725-0
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DOI: https://doi.org/10.1007/s11094-012-0725-0