A series of 4-aroyl-1H-benzo[c]oxepin-4-ones have been prepared by heating ethyl 2-aroyl-3-(2-bromophenyl)propenoates. The synthesized compounds possess higher analgesic activity than the reference drug (analgin) and exhibit low toxicity.
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The work was carried out with financial support of the Russian Foundation for Basic Research (Grant No. 07-03-96035).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 9, pp. 17 – 18, September, 2010.
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Glukhov, A.A., Kirillov, N.F., Potapova, A.A. et al. Synthesis and analgesic activity of 4-aroyl-1H-benzo[c]oxepin-3-ones. Pharm Chem J 44, 483–485 (2010). https://doi.org/10.1007/s11094-010-0497-3
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DOI: https://doi.org/10.1007/s11094-010-0497-3