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The hypolipidemic action of trecrezan and its possible molecular mechanisms

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

The experiments reported here demonstrated that prophylactic use of trecrezan delayed the development of atherosclerosis in rabbits, with decreases in aortic atherosclerotic plaques and reductions in cholesterol, triacylglycerols, and β-lipoprotein levels in serum, liver, and aortic tissue. Trecrezan accelerated the synthesis of tryptophanyl tRNA synthetase, which is the key component in the complex mechanism of action of this agent.

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Authors and Affiliations

  1. State Higher Professional Educational Institution Moscow City Pedagogical University, Moscow, Russia

    M. M. Rasulov, M. K. Nurbekov, S. N. Bobkova, V. V. Bulanova, E. S. Antonova & M. I. Susova

  2. Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia

    M. G. Voronkov

Authors
  1. M. M. Rasulov
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  2. M. K. Nurbekov
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  3. S. N. Bobkova
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  4. V. V. Bulanova
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  5. E. S. Antonova
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  6. M. I. Susova
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  7. M. G. Voronkov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 6, pp.3–6, June, 2010.

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Rasulov, M.M., Nurbekov, M.K., Bobkova, S.N. et al. The hypolipidemic action of trecrezan and its possible molecular mechanisms. Pharm Chem J 44, 287–290 (2010). https://doi.org/10.1007/s11094-010-0451-4

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  • DOI: https://doi.org/10.1007/s11094-010-0451-4

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