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Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
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Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.

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Authors and Affiliations

  1. Lomonosov Moscow State Academy of Fine Chemical Technology, Moscow, Russia

    G. M. Sorokoumova, V. V. Vostrikov & E. A. Rogozhkina

  2. Department of Biology, Lomonosov Moscow State University, Moscow, Russia

    A. A. Selishcheva, T. Yu. Kalashnikova & V. I. Shvets

  3. Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences, Msocow, Russia

    V. I. Golyshevskaya, L. P. Martynova & V. V. Erokhin

Authors
  1. G. M. Sorokoumova
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  2. V. V. Vostrikov
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  3. A. A. Selishcheva
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  4. E. A. Rogozhkina
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  5. T. Yu. Kalashnikova
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  6. V. I. Shvets
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  7. V. I. Golyshevskaya
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  8. L. P. Martynova
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  9. V. V. Erokhin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 10, pp. 35–38, October, 2008.

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Sorokoumova, G.M., Vostrikov, V.V., Selishcheva, A.A. et al. Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition. Pharm Chem J 42, 475–478 (2008). https://doi.org/10.1007/s11094-008-0153-3

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  • DOI: https://doi.org/10.1007/s11094-008-0153-3

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