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Chemical composition and pharmacological activity of anthraquinones from Rubia cordifolia cell culture

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Abstract

The results of qualitative and quantitative determination of anthraquinones in Indian madder (Rubia cordifolia L.) cell culture are presented. According to the 1H and 13C NMR, UV, IR, and mass-spectroscopic data, seven anthraquinones have been identified, in which munjistin and purpurin are predominant. The cell culture preparation exhibits antiinflammatory activity, which is manifested by an antiexudative effect and antiproliferative action during the rapid development of a model edema. Adecrease in the antioxidant state without significant suppression of enzymatic activity is demonstrated.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, Far-Eastern Division, Russian Academy of Sciences, Vladivostok, 690022, Russia

    N. P. Mishchenko & S. A. Fedoreev

  2. Altai State Medical University, Barnaul, Altai Territory, 656038, Russia

    V. M. Bryukhanov, Ya. F. Zverev, V. V. Lampatov & O. V. Azarova

  3. Institute of Biology and Soil Science, Far-Eastern Division, Russian Academy of Sciences, Vladivostok, 690022, Russia

    Yu. N. Shkryl’ & G. K. Chernoded

Authors
  1. N. P. Mishchenko
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  2. S. A. Fedoreev
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  3. V. M. Bryukhanov
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  4. Ya. F. Zverev
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  5. V. V. Lampatov
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  6. O. V. Azarova
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  7. Yu. N. Shkryl’
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  8. G. K. Chernoded
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 11, pp. 38–41, November, 2007.

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Mishchenko, N.P., Fedoreev, S.A., Bryukhanov, V.M. et al. Chemical composition and pharmacological activity of anthraquinones from Rubia cordifolia cell culture. Pharm Chem J 41, 605–609 (2007). https://doi.org/10.1007/s11094-008-0021-1

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  • DOI: https://doi.org/10.1007/s11094-008-0021-1

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