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Synthesis and antimicrobial activity of 1,2-diaryl-and 2,3-diaryl-(2-aryl-3-n-arylamino)-1,2,3,4-tetrahydroquinazolin-4-ones

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Abstract

New 2,3-diaryl-(2-aryl-3-N-arylamino)-and 1,2-diaryl-1,2,3,4-tetrahydroquinazolin-4-ones were obtained via reactions of arylamides and anthranilic acid phenylhydrazide or N-arylanthranilic acid amides with 5-bromo-or 5-nitrosalicylic aldehydes. One of these compounds was acetylated to a triacetyl derivative. The structures of the synthesized compounds were determined by spectral methods (1H NMR, IR) and their antimicrobial activity was evaluated.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    O. E. Sattarova, O. L. Vizgunova & É. V. Voronina

Authors
  1. O. E. Sattarova
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  2. O. L. Vizgunova
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  3. É. V. Voronina
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 2, pp. 15–16, February, 2006.

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Sattarova, O.E., Vizgunova, O.L. & Voronina, É.V. Synthesis and antimicrobial activity of 1,2-diaryl-and 2,3-diaryl-(2-aryl-3-n-arylamino)-1,2,3,4-tetrahydroquinazolin-4-ones. Pharm Chem J 40, 73–75 (2006). https://doi.org/10.1007/s11094-006-0061-3

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  • DOI: https://doi.org/10.1007/s11094-006-0061-3

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