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X-shaped exposed core highly sensitive plasmonic sensor for cancer cell detection

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Abstract

For accurate bio-sample identification, we present a unique optimized surface plasmon resonance sensor based on an X-shaped exposed-core photonic crystal fiber. Applications are made easier by the placement of the target analyte and plasmonic material on the fiber’s exterior surface. The sensor has four separate silica channels that reach from the core to the metallic outer surface creating X-shape. These channels were intentionally placed to provide the highest sensitivity while maintaining the sensor’s ability to be manufactured. Within a refractive index range of 1.33 to 1.40, our optimized sensor demonstrates improved detecting abilities, including a wavelength sensitivity of 8000 nm/RIU and amplitude sensitivity of \(-\)1175.12 \(RIU^{-1}\). The suggested sensor also exhibits exceptional performance parameters, such as a resolution of \(1.25\times 10^{-5}\), a maximum signal-to-noise ratio (SNR) of 2.041 dB, a figure of merit (FOM) of 160.0 \(RIU^{-1}\), a detection accuracy (DA) of 0.02 nm−1, and minimum full width half maxima (FWHM) of 50 nm. When examining variations in the optical properties of the PCF due to different RIs of normal and cancer cells using finite element analysis, we achieve amplitude sensitivities of \(-\)844.91, \(-\)418 and \(-\)1221.8 \(RIU^{-1}\) for HeLa, Basal and MDA-MB-231 cell lines, respectively.

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Data underlying the results presented in this paper is not publicly available at this time but may be obtained from the authors upon reasonable request.

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Acknowledgements

This research work was funded by Institutional Fund Projects under Grant No. (IFPIP: 961-135-1443). The authors gratefully acknowledge technical and financial support provided by the Ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi Arabia.

Funding

This research work was funded by Institutional Fund Projects under Grant No. (IFPIP: 961-135-1443).

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Authors and Affiliations

  1. Department of Electronics and Telecommunication Engineering, Rajshahi University of Engineering and Technology, Rajshahi, 6204, Bangladesh

    Afiquer Rahman, Mehedi Hasan Pappu & Md. Aslam Mollah

  2. Department of Electrical and Computer Engineering, Faculty of Engineering, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Md. Shofiqul Islam, Ibrahim Mustafa Mehedi & Sami Alghamdi

  3. Department of Physics, College of Science, University of Jeddah, Jeddah, Saudi Arabia

    M. Alharbi

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  1. Afiquer Rahman
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Contributions

Conceptualization, M.A.M, M.S.I., and A.R.; methodology, A.R., M.S.I, M.A.; software, A.R., M.H.P., and M.A.M.; validation, S.A., M.S.I., M.A., M.H.P., I.M.M., and M.A.M.; formal analysis, M.H.P., M.A.M.; investigation, M.A.M.; resources, M.S.I., M.A., and M.A.M.; data curation, M.A., I.M.M.; writing—original draft preparation, A.R., M.H.P. M.A.M.; writing—review and editing, A.R., M.S.I., M.A., and I.M.M..; visualization, S.A., and M.A.M; supervision, M.A.M.; project administration, M.A.M.; funding acquisition, M.S.I., M.A., I.M.M., S.A., All authors have read and agreed to the published version of the manuscript.

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Correspondence to Md. Aslam Mollah.

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Rahman, A., Islam, M.S., Alharbi, M. et al. X-shaped exposed core highly sensitive plasmonic sensor for cancer cell detection. Opt Quant Electron 56, 718 (2024). https://doi.org/10.1007/s11082-024-06392-w

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