Abstract
In this work, a single and dual rhombic-shaped ring resonator (RR) bio-sensor using 2D photonic crystal (2D-PhC) are designed and simulated with circular Si rods in a square lattice in an air arrangement. The photonic band gap (PBG) of the structure is calculated using plane wave expansion (PWE) method. The simulation and investigation of the bio-sensor structure is carried out using finite-difference time-domain (FDTD) method. The optimized simulation parameters like rod radius, lattice constant, angle of incidence and cavity thickness are 142 nm, 630 nm, 90° and 2 μm respectively. A small change in refractive index (RI) will cause a considerable shift in the resonant wavelength and transmission output. The proposed bio-sensor is capable of analyzing eleven different components of blood based on the RI. Many blood-related disorders such as nutritional deficiency, inflammatory bowel disease (IBD), leukemia, lymphoma and thalassemia can be found using this bio-sensor in less time and with minimum human effort. The average quality factor (QF), sensitivity and transmission efficiency (η) of the bio-sensor are 3702, 166 (nm/RIU) and 80% respectively. This design is instigated for medical applications with a compactness of 515.29 μm2.
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Al-Dossari, M., Aswathi, S.K., Mohamed, A.M., Abd-El-Gawaad, N.S., Sabra, W., Aly, A.H.: Bio-alcohol sensor based on one-dimensional photonic crystals for detection of organic materials in wastewater. Materials 15(11), 4012 (2022). https://doi.org/10.3390/ma15114012
Aly, A.H.: Superconductor-dielectric photonic band gap in ultraviolet radiation. Int. J. Adv. Appl. Phys. Res. Special, 43–47 (2016). https://doi.org/10.1537/2408-977X.2016.04
Aly, A.H., Mohamed, D.: The optical properties of metamaterial-superconductor photonic band gap with/without defect layer. J. Supercond. Nov Magn. 32, 1897–1902 (2019). https://doi.org/10.1007/s10948-018-4922-2
Aly, A.H., Elsayed, H.A., El-Naggar, S.A.: The properties of cutoff frequency in two-dimensional superconductor photonic crystals. J. Mod. Opt. 61(13), 1064–1068 (2014). https://doi.org/10.1080/09500340.2014.916358
Aly, A.H., Awasthi, S.K., Mohaseb, M.A., Matar, Z.S., Amin, A.F.: MATLAB simulation-based theoretical study for detection of a wide range of pathogens using 1D defective photonic structure. Crystals 12, 220 (2022). https://doi.org/10.3390/cryst12020220
American Society of Hematology. http://www.hematology.org/Patients/Basics/. 4 November 2018
Amiri, I.S., Paul, B.K., Ahmed, K., Aly, A.H., Zakaria, R., Yupapin, P., Vigneswaran, D.: Tri-core photonic crystal fiber based refractive index dual sensor for salinity and temperature detection. Microwave Opt. Technol. Lett. 61(3), 847–852 (2019)
Anderson, N.L., Anderson, N.G.: The human plasma proteome history, character, and diagnostic prospects. Mol. Cell. Proteom. 1, 845–867 (2002)
Areed, N.F.F., Hameed, M.F.O., Obayya, S.S.A.: Highly sensitive face-shaped label free photonic crystal refractometer for glucose concentration monitoring. Opt. Quantum Electron. 49, 1–12 (2017)
Arunkumar, R., Suganya, T., Robinson, S.: Design and analysis of photonic crystal elliptical ring resonator based pressure sensor. Int. J. Photonics Opt. Technol. 3(1), 30–33 (2017)
Arunkumar, R., Suganya, T., Robinson, S.: Design and analysis of 2D photonic crystal based biosensor to detect different blood components. Photonic Sens. 9(1), 69–77 (2019)
Biswas, U., Rakshit, J.K.: Detection and analysis of haemoglobin concentration in blood with the help of photonic crystal based micro ring resonator structure. Opt. Quantum Electron. 52, 10 (2020). https://doi.org/10.1007/s11082-020-02566-4
Biswas, U., Rakshit, J.K., Bharti, G.K.: Design of photonic crystal microring resonator based all-optical refractive-index sensor for analyzing different milk constituents. Opt. Quantum Electron. 52(1), 19 (2020)
Chen, Y., Wang, W., Zhu, Q.: Theoretical study on biosensing characteristics of heterostructure photonic crystal ring resonator. Opt. Int. J. Light Electron. Opt. 125(15), 3931–3934 (2014)
Chopra, H., Kaler, R.S., Painam, B.: Photonic crystal waveguide-based biosensor for detection of diseases. J. Nanophotonics 10, 036011 (2016)
Danaie, M., Kiani, B.: Design of a label-free photonic crystal refractive index sensor for biomedical applications. Photonics Nanostruct. Fundam. Appl. (2018). https://doi.org/10.1016/j.photonics.2018.06.004
Garvin, Jr., J. H.: Gender-specific aspects of pediatric hematology and oncology. In: Principles of Gender-Specific Medicine, 2nd edn, pp. 51–61. Academic Press (2010). https://doi.org/10.1016/C2009-0-03574-0
Gudagunti, F.D., Sharma, P., Talabattula, S., Nainitej, V.: Early-stage detection of breast cancer using hybrid photonic crystal ring resonator. In: Proceeding of IEEE International Conference on Advanced Communication Control and Computing Technologies, Ramanathapuram, pp. 1–4 (2014)
Harraz, F.A.: Porous silicon chemical sensors and biosensors: a review. Sens. Actuators B Chem. 202, 897–912 (2014)
Hosseinzadeh, A., Middlebrook, C.T.: Highly linear dual ring resonator modulator for wide bandwidth microwave photonic links. Opt. Express 24(24), 27268 (2016). https://doi.org/10.1364/oe.24.027268
Jackson, J.D.: Classical Electrodynamics. Wiley, New York (1962). https://doi.org/10.1063/1.3057859
Joannopoulos, J.D., Villeneuve, P.R., Fan, S.: Photonic crystals: putting a new twist on light. Nature 386(6621), 143–149 (1997)
Joannopoulos, J.D., Johnson, S.G., Winn, J.N., Meade, R.D.: Photonic Crystals: Molding the Flow of Light. Princeton University Press (2011)
Meade, R.D., Rappe, A.M., Brommer, K.D., Joannopoulos, J.D.: Existence of a photonic band gap in two dimensional. Appl. Phys. Lett. 61(4), 495–497 (1992)
Mohamed, M.S., Hameed, M.F.O., Areed, N.F.F., El-Okr, M.M., Obayya, S.S.A.: Analysis of highly sensitive photonic crystal biosensor for glucose monitoring. J. ACES 31, 836–842 (2016)
Mohammed, N.A., Hamed, M.M., Khalaf, A.A.M., Alsayyari, A., EL-Rabaie, S.: High-sensitivity ultra-quality factor and remarkable compact blood components biomedical sensor based on nanocavity coupled photonic crystal. Results Phys. 14, 102478 (2019). https://doi.org/10.1016/j.rinp.2019.102478
Natesan, A., Govindasamy, K.P., Gopal, T.R., Dhasarathan, V., Aly, A.H.: Tricore photonic crystal fibre based refractive index sensor for glucose detection. IET Optoelectron. 13(3), 118–123 (2019). https://doi.org/10.1049/iet-opt.2018.5079
Olyaee, S., Bahabady, A.M.: Design and optimization of diamond-shaped biosensor using photonic crystal nano-ring resonator. Opt. Int. J. Light Electron. Opt. 26(20), 2560–2564 (2015). https://doi.org/10.1016/j.ijleo.2015.06.037
Painam, B., Kaler, R.S., Kumar, M.: Active layer identification of photonic crystal waveguide biosensor chip for the detection of Escherichia coli. Opt. Eng. 55, 077105 (2016)
Parandin, F., Heidari, F., Aslinezhad, M., et al.: Design of 2D photonic crystal biosensor to detect blood components. Opt. Quantum Electron. 54, 618 (2022). https://doi.org/10.1007/s11082-022-03945-9
Rajasekar, R., Jayabarathan, J.K., Robinson, S.: Nano-optical filter based on multicavity coupled photonic crystal ring resonator. Phys. E Low-Dimens. Syst. Nanostruct. 114, 11359 (2019). https://doi.org/10.1016/j.physe.2019.113591
Robinson, S., Nakkeeran, R.: Advances in Photonic Crystals || Photonic Crystal Ring Resonator Based Optical Filters (2013). https://doi.org/10.5772/54533
Robinson, S., Dhanlaksmi, N.: Photonic crystal based biosensor for the detection of glucose concentration in urine. Photonic Sens. 7(1), 11–19 (2016). https://doi.org/10.1007/s13320-016-0347-3
Robinson, S., Shanthi, K.V.: Analysis of protein concentration based on photonic crystal ring resonator. Int. J. Opt. Photonics 10, 123–130 (2016)
Santos, H.A.: Porous Silicon for Biomedical Applications. Elsevier, Amsterdam (2014)
Sharan, P., Bharadwaj, S.M., Gudagunti, F.D., Deshmukh, P.: Design and modeling of photonic sensor for cancer cell detection. In: International Conference on the Impact of E-Technology on US, vol. 40, no. 14, pp. 20–25 (2014)
Sharma, S., Kumar, A., Singh, Kh.S., Tyagi, H.K.: 2D photonic crystal based biosensor for the detection of chikungunya virus. Optik 237, 16657 (2021). https://doi.org/10.1016/j.ijleo.2021.166575
Sreekanth, K.V., ElKabbash, M., Medwal, R., Zhang, J., Letsou, T., Strangi, G., Hinczewski, M., Rawat, R.S., Guo, C., Singh, R.: Generalized brewster angle effect in thin-film optical absorbers and its application for graphene hydrogen sensing. ACS Photonics 6, 1610–1617 (2019). https://doi.org/10.1021/acsphotonics.9b00564
Suganya, T., Robinson, S.: 2D photonic crystal based biosensor using Rhombic ring resonator for glucose monitoring. J. Microelectron. 3, 349–353 (2017)
Thenmozhi, H., Rajan, M.M., Devika, V., Vigneswaran, D., Ayyanar, N.: D-glucose sensor using photonic crystal fiber. Opt. Int. J. Light Electron. Opt. 145, 489–494 (2017)
Venkatachalam, K., Robinson, S., Kumar, D.S.: AIP Conference Proceedings [Author(s) LET THERE BE LIGHT: Reflections of a Congress on Light - Kerala, India (9–11 January 2017)]—Design and analysis of dual ring resonator based 2D-photonic crystal WDDM, 020016 (2017). https://doi.org/10.1063/1.4984163
Xu, Y., Hu, X., Kundu, S., Nag, A., Afsarimanesh, N., Sapra, S., Mukhopadhyay, S.C., Han, T.: Silicon-based sensors for biomedical applications: a review. Sensors 19(13), 2908 (2019). https://doi.org/10.3390/s19132908
Yaroslavsky, A.N., Yaroslavsky, I.V., Goldbach, T., Schwarzmaier, H.J.: The optical properties of blood in the near infrared spectral range. Proc. SPIE 2678, 314–324 (1996)
Zhao, Y., Zhang, Y.N., Lv, R.Q., Li, J.: Electric field sensor based on photonic crystal cavity with Liquid crystal infiltration. J. Lightwave Technol. 35, 3440–3446 (2017)
Zhernovaya, O., Sydoruk, O., Tuchin, V., Douplik, A.: The refractive index of human hemoglobin in the visible range. Phys. Med. Biol. 56(13), 4013 (2011)
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BK: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing—original draft. ECB, MM, ST: Supervision, Validation, Visualization, Writing—review & editing.
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Krishnamoorthi, B., Elizabeth Caroline, B., Michael, M. et al. A novel rhombic shaped photonic crystal bio-sensor for identifying disorders in the blood samples. Opt Quant Electron 55, 312 (2023). https://doi.org/10.1007/s11082-023-04584-4
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DOI: https://doi.org/10.1007/s11082-023-04584-4