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Transient Receptor Potential Channels: Multiple Modulators of Peripheral Neuropathic Pain in Several Rodent Models

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Abstract

Neuropathic pain, a prevalent chronic condition in clinical settings, has attracted widespread societal attention. This condition is characterized by a persistent pain state accompanied by affective and cognitive disruptions, significantly impacting patients’ quality of life. However, current clinical therapies fall short of addressing its complexity. Thus, exploring the underlying molecular mechanism of neuropathic pain and identifying potential targets for intervention is highly warranted. The transient receptor potential (TRP) receptors, a class of widely distributed channel proteins, in the nervous system, play a crucial role in sensory signaling, cellular calcium regulation, and developmental influences. TRP ion channels are also responsible for various sensory responses including heat, cold, pain, and stress. This review highlights recent advances in understanding TRPs in various rodent models of neuropathic pain, aiming to uncover potential therapeutic targets for clinical management.

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Data Availability

The data that support the findings of this study are available from the corresponding author, [Yun Wang], upon reasonable request.

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Acknowledgements

The authors thank Home for Researchers (www.home-for-researchers.com) for English language editing. Figures were created by BioRender (Publication Permissions: JA264FWIEQ; KP264FWQ0C; MF264JVU2N).

Funding

This work was supported by the National Natural Science Foundation of China (81771181, 81571065, 82171217) and the Beijing Natural Science Foundation (7202053).

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  1. Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong’an Road, Xicheng District, Beijing, 100050, China

    Songchao Xu & Yun Wang

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  1. Songchao Xu
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  2. Yun Wang
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All authors made a significant contribution to the work. SX: literature search and selection, content writing, figure and table creation. YW: conceptualization, structure design, content revision and funding acquisition.

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Correspondence to Yun Wang.

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Xu, S., Wang, Y. Transient Receptor Potential Channels: Multiple Modulators of Peripheral Neuropathic Pain in Several Rodent Models. Neurochem Res 49, 872–886 (2024). https://doi.org/10.1007/s11064-023-04087-4

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