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Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System

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Abstract

Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major cell types remodel their shape, generate unsurpassed quantities of membranes and extend cellular processes to communicate, and regulate the activities of other cells. Herein, we analyze two microtubule regulatory alpha-tubulin deacetylases, histone deacetylase-6 (HDAC6) and SirT2. HDAC6 is expressed by most neurons but is abundant in cerebellar Purkinje cells. In contrast, SirT2 is targeted to myelin sheaths. Expression of these proteins by post-mitotic cells indicates novel functions, such as process outgrowth and membrane remodeling. In oligodendrocytes, targeting of SirT2 to paranodes coincides with the presence of the microtubule-destabilizing protein stathmin-1 during early myelinogenesis and suggests the existence of a microtubule regulatory network that modulates cytoskeletal dynamics.

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Acknowledgments

This work was supported by grants to A.G. from NINDS, NIH (NS43783) and the National Multiple Sclerosis Society (RG2891).

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Authors and Affiliations

  1. Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3216 Scott Hall, 540 E Canfield Ave., Detroit, MI , 48201, USA

    Cherie M. Southwood, Marcello Peppi, Michael A. Tainsky & Alexander Gow

  2. Karmanos Cancer Center, Wayne State University School of Medicine, 110 E Warren, Detroit, MI, 48201, USA

    Sylvia Dryden & Michael A. Tainsky

  3. Department of Pathology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI, 48201, USA

    Michael A. Tainsky

  4. Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI, 48201, USA

    Alexander Gow

  5. Department of Neurology, Wayne State University School of Medicine, 4210 St Antoine, Detroit, MI, 48201, USA

    Alexander Gow

Authors
  1. Cherie M. Southwood
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  2. Marcello Peppi
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  3. Sylvia Dryden
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  4. Michael A. Tainsky
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  5. Alexander Gow
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Correspondence to Alexander Gow.

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Special issue dedicated to Dr. Anthony Campagnoni.

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Southwood, C.M., Peppi, M., Dryden, S. et al. Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System. Neurochem Res 32, 187–195 (2007). https://doi.org/10.1007/s11064-006-9127-6

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  • DOI: https://doi.org/10.1007/s11064-006-9127-6

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