Skip to main content

Advertisement

SpringerLink
Log in

Age-related Decline of Brain Monoamines in Mice is Reversed to Young Level by Japanese Herbal Medicine

  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

Young (3-month-old) and aged mice (18-month-old) were fed a diet containing Japanese herbal medicine (TJ-41 or TJ-48) for 5 months, and the effect of the herbal medicines were examined in terms of levels of monoamines and their metabolites in the brain of young and aged mice. In the aged mice, the levels of norepinepherine, serotonin and their metabolites in the brain were decreased in the cortex, hippocampus and hypothalamus. Feeding of diet containing TJ-48, but not TJ-41, enhanced the levels of some monoamines and their metabolites in the brains of aged mice, comparable to those of young mice. The results indicated that the improvement of levels of monoamines by Japanese herbal medicine was observed only in the aged mice, not in the young mice. The data have suggested the importance of the aged animals to see the effect of medicine on the functions of organs or systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • N. W. Shock (1970) ArticleTitlePhysiological aspect of aging J. Am. Diet. Assoc. 56 491–496

    Google Scholar 

  • K. Hirokawa M. Utsuyama (2002) ArticleTitleAnimal models and possible human application of immunological restoration in the elderly Mech. Ageing Dev. 123 1055–1063 Occurrence Handle10.1016/S0047-6374(01)00389-X

    Article  Google Scholar 

  • M. Utsuyama H. Seidlar M. Kitagawa K. Hirokawa (2001) ArticleTitleImmunological restoration and anti-tumor effect by Japanese herbal medicine in aged mice Mech. Ageing Dev. 122 341–352 Occurrence Handle10.1016/S0047-6374(00)00249-9

    Article  Google Scholar 

  • M. Utsuyama K. Hirokawa (2002) ArticleTitleDifferential expression of various cytokine receptors in the brain after stimulation with LPS in young and aged mice Exp. Gerontol. 37 411–420 Occurrence Handle10.1016/S0531-5565(01)00208-X

    Article  Google Scholar 

  • R. D. Oades K. Taghzouti J. Ml Rivet H. Simon M. Le Moal (1986) ArticleTitleLocomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontal areas: A 6-hydroxydopamine study Neuropsychobiology 16 37–42

    Google Scholar 

  • C. Fujisaki M. Utsuyama Y. Kuroda A. Watanabe H. Seidlar S. Watanabe M. Kitagawa K. Hirokawa (2003) ArticleTitleAn immunosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress J. Med. Dent. Sci. 50 93–100

    Google Scholar 

  • Robertson, R. T., Zimmer, J., and Gähwiler, B. H. 1989, Dissection procedures for preparation of slide cultures. Pages 1–15, in: A Dissection and Tissue Culture Manual of the Nervous System. Alan R. Liss, Inc.

  • J. E. Downing J. A. Myan (2000) ArticleTitleNeural immunoregulation: Emerging roles for nerves in immune homeostasis in immune and diseases Immunol. Today 21 37–43 Occurrence Handle10.1016/S0167-5699(00)01635-2

    Article  Google Scholar 

  • H. A. Besedovsky A. del Rey (1996) ArticleTitleImmune-neuro-endocrine interactions; facts and hypotheses Endocr. Rev. 17 64–102 Occurrence Handle10.1210/er.17.1.64

    Article  Google Scholar 

  • C. Todorovic M. Dimitrijevic S. Stanojevic V. Kovacevic-Jovanovic T. Miletic O. Laban J. Radulovic (2003) ArticleTitleCorrelation between age-related changes in open field behavior and plaque forming cell response in DA female rats Int. J. Neurosci. 113 1259–1273 Occurrence Handle10.1080/00207450390212492

    Article  Google Scholar 

  • Hirokawa, K. 1998. Immunity and aging. Pages 35–47, in Pathy, M. S. J. (ed.), Principle and practice of geriatric medicine. London: Wiley.

  • H. Watanabe M. Hagiwara M. Tohda Y. Hiyama K. Terasawa K. Watanabe (1984) ArticleTitleCentral effects of cinnamaldehyde Yakugaku Zasshi 104 1095–1100

    Google Scholar 

  • F. Godefroy M. H. Bassant Y. Lamour J. Weil-Fugazza (1991) ArticleTitleEffect of aging on dopamine metabolism in the rat cerebral cortex: A regional analysis J. Neural Transm. Gen. Sect. 83 13–24

    Google Scholar 

  • J. W. Haycock L. Becker L. Ang Y. Furukawa O. Hornkiewicz S. J. Kishi (2003) ArticleTitleMarked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum J. Neurochem. 87 574–685 Occurrence Handle10.1046/j.1471-4159.2003.02017.x

    Article  Google Scholar 

  • W. Reimann G. D. Bartoszyk U. Kollhofer F. Schneider U. Schoenherr (1993) ArticleTitleEffects of ageing and long-term operant conditioning on behavior and presynaptic cholinergic and dopaminergic neuronal mechanisms in rats Arch. Int. Pharmacodyn. Ther. 325 5–20

    Google Scholar 

  • J. J. Lee C. K. Chang I. M. Liu T. C. Chi H. J. Yu J. T. Cheng (2001) ArticleTitleChanges in endogenous monoamines in aged rats Clin. Exp. Pharmacol. Physiol. 28 285–289 Occurrence Handle10.1046/j.1440-1681.2001.03439.x

    Article  Google Scholar 

  • A. Moretti N. Carfagna F. Trunzo (1987) ArticleTitleEffect of aging on monoamines and their metabolites in the rat brain Neurochem. Res. 12 1035–1039 Occurrence Handle10.1007/BF00970933

    Article  Google Scholar 

  • J. M. Migues M. Aldegunde L. Paz-Valinas J. Recio E. Sanchez-Barcelo (1999) ArticleTitleSelective changes in the contents of noradrenaline, dopamine and serotonin in rat brain areas during aging J. Neural Transm. 106 1089–1098 Occurrence Handle10.1007/s007020050225

    Article  Google Scholar 

  • E. M. Gardner D. M. Murasko (2002) ArticleTitleAge-related changes in Type 1 and Type 2 cytokine production in humans Biogerontol 3 271–290 Occurrence Handle10.1023/A:1020151401826

    Article  Google Scholar 

  • A. Wakikawa M. Utsuyama A. Wakabayashi M. Kitagawa K. Hirokawa (1999) ArticleTitleAge-related alteration of cytokine production profile by T cell subsets in mice: A flow cytometric study Exp. Gerontol. 34 231–242 Occurrence Handle10.1016/S0531-5565(98)00062-X

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Immunology, Tokyo Medical & Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    A. Tsunemi, M. Utsuyama, B. K. H. Seidler & K. Hirokawa

  2. Neuronal Function Research Group, Tokyo Metropolitan Institute of Gerontology, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    M. Utsuyama & S. Kobayashi

  3. Department of Pathology and Immunology, Tokyo Medical & Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    K. Hirokawa

Authors
  1. A. Tsunemi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Utsuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. K. H. Seidler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Hirokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Hirokawa.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tsunemi, A., Utsuyama, M., Seidler, B.K.H. et al. Age-related Decline of Brain Monoamines in Mice is Reversed to Young Level by Japanese Herbal Medicine. Neurochem Res 30, 75–81 (2005). https://doi.org/10.1007/s11064-004-9688-1

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11064-004-9688-1

Keywords

Search

Navigation