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Peculiarities of the Effects of Stimulation of Emotiogenic Central Structures under Conditions of a Kindling Model of Epilepsy

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Neurophysiology Aims and scope

In our study, we tried, first, to elucidate whether induction of emotional behavior resulting from stimulation of the dorsomedial hypothalamus (DMH) influences the development of seizure activity in the course of epileptogenesis within the framework of fast kindling (stimulation of the hippocampus) and, second, to estimate if such stimulation is capable of modulating manifestations of generalized seizures under conditions of the pre-formed “full” epileptic syndrome. Stimulation of the DMH in the above two experimental situations resulted in significant suppression of both electrographic and behavioral manifestations of seizure activity. We hypothesize that the respective emotional reactions can be interpreted as phenomena of instinctive behavior having an adaptive defensive significance. These reactions are related to inhibitory processes providing protection from the development of seizure activity.

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References

  1. S. J. Swanson, S. M. Rao, J. Grafman, et al., “The relationship between seizure subtype and interictal personality. Results from the Vietnam head injury study,” Brain, 118, 91–103 (1995).

    Article  PubMed  Google Scholar 

  2. M. Trimble, “Epilepsy and behavior,” Epilepsy Res., 10, 71–79 (1991).

    Article  PubMed  CAS  Google Scholar 

  3. N. C. de Lanerolle, J. H. Kim, R. J. Robbins, and D. D. Spenser, “Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy,” Brain Res., 495, No. 2, 387–395 (1989).

    Article  PubMed  Google Scholar 

  4. P. Conlon and M. R. Trimble, “MRI in epilepsy: a controlled study,” Epilepsy Res., 2, No. 1, 37–43 (1988).

    Article  PubMed  CAS  Google Scholar 

  5. K. Moritomo, M. Fahnestock, and R. Racine, “Kindling and status epilepticus models of epilepsy,” Prog. Neurobiol., 73, No. 1, 1–60 (2004).

    Article  Google Scholar 

  6. G. Goddard, D. McIntyre, and C. Leech, “A permanent change in brain function resulting from daily electrical stimulation,” Exp. Neurol., 25, No. 1, 295–330 (1969).

    Article  PubMed  CAS  Google Scholar 

  7. R. Adamec and D. McKay, “Amygdala kindling, anxiety and corticotropin releasing factor,” Physiol. Behav., 54, No. 2, 423–431 (1993).

    Article  PubMed  CAS  Google Scholar 

  8. L. Kalynchuk, J. Pinel, D. Treit, et al., “Persistence of the interictal emotionality produced by long-term amygdala kindling in rats,” Neuroscience, 85, No. 3, 1311–1319 (1998).

    Article  PubMed  CAS  Google Scholar 

  9. L. Kalynchuk, “Long-term amygdala kindling in rats as a model for the study of interictal emotionality in temporal lobe epilepsy,” Neurosci. BioBehav. Rev., 24, No. 2, 691–704 (2000).

    Article  PubMed  CAS  Google Scholar 

  10. S. Waxman and N. Geschwind, “The interictal behavior syndrome in temporal lobe epilepsy,” Arch. Gen. Psychiat., 32, No. 4, 1580–1586 (1975).

    Article  PubMed  CAS  Google Scholar 

  11. J. Engel, Jr. Seizures and Epilepsy, PA-FA, Davis, Philadelphia (1989).

    Google Scholar 

  12. R. Fisher and J. Kerrigan, “Vigabatrin. Toxicity,” in: Antiepileptic Drugs, R. Lery, R. Mattson, and B. Meldrum (eds.), Raven Press, New York (1995), pp. 931–940.

    Google Scholar 

  13. G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates. Academic Press, New York, (1997).

    Google Scholar 

  14. R. J. Racine, “Modification of seizure activity by electrical stimulation: II. Motor seizures,” Electroencephalogr. Clin. Neurophysiol., 32, No. 2, 281 (1972).

    PubMed  CAS  Google Scholar 

  15. B. B. Brown, “Frequency and phase of hippocampal theta activity in the spontaneously behaving cat,” Electroencephalogr. Clin. Neurophysiol., 24, No. 1, 53–62 (1968).

    Article  PubMed  CAS  Google Scholar 

  16. G. Buzsaki, Lai-Wo Leung, and C. H. Vanderwolf, “Cellular bases of hippocampal EEG in the behaving rat,” Brain Res., 6, No. 1, 139–171 (1983).

    Google Scholar 

  17. J. D. Green and A. J. Arduini, “Hippocampal electrical activity in arousal,” J. Neurophysiol., 17, No. 6, 553–557 (1954).

    Google Scholar 

  18. C. H. Vanderwolf, R. Kramis, T. E. Robinson, “Hippocampal electrical activity during waking behavior and sleep: analysis using centrally acting drugs,” in: Functions of Septo-Hippocampal System. Ciba Foundation Symposium, K. Elliot and J. Whelan (eds.), Vol. 58, London (1978), pp. 199–221.

  19. G. Ferraro, P. Sardo, M. Sabatino, and V. La Grutta, “Locus coeruleus noradrenaline system and focal penicillin hippocampal epilepsy: Neurophysiological study,” Epilepsy Res., 19, No. 1, 215–220 (1994).

    Article  PubMed  CAS  Google Scholar 

  20. T. K. Ioseliani, Z. I. Nanobashvili, and N. A. Khizanishvili, “Changes in seizure activity thresholds of cat brain in various stages of sleep and wakefulness,” Neurophysiology, 6, No. 6, 454–460 (1974).

    Google Scholar 

  21. V. C. Euler and J. D. Green, “Excitation, inhibition and rhythmic activity in hippocampal cells in rabbit,” Acta Physiol. Scand., 48, No. 1, 110–125 (1960).

    Article  Google Scholar 

  22. G. Buzsaki and G. Czeh, “Commissural and perforant path interactions in the rat hippocampus: field potentials and unitary activity,” Exp. Brain Res., 43, No. 3, 429–438 (1981).

    Article  PubMed  CAS  Google Scholar 

  23. G. Buzsaki and E. Eidelberg, “Direct afferent excitation and long-term potentiation of hippocampal interneurons,” J. E. Psychiatry, 48, No. 3, 397–607 (1982).

    Google Scholar 

  24. T. F. Freund and G. Buzsaki, “Interneurons of the hippocampus,” Hippocampus, 6, 347–470 (1996).

    Article  PubMed  CAS  Google Scholar 

  25. S. I. Neophytou, U. E. Aspley, S. Butler, et al., “Effects of lesioning noradrenergic neurons in the locus coeruleus on conditioned and anconditioned aversive behavior in the rat,” Prog. Neuro-Psychopharmacol. Biol. Psychiat., 25, No. 6, 1307–1321 (2001).

    Article  CAS  Google Scholar 

  26. F. S. Giorgi, M. Ferrucci, G. Lazzeri, et al., “A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus,” Eur. J. Neurosci., 17, No. 4, 2593–2061 (2003).

    Article  PubMed  Google Scholar 

  27. G. K. Weiss, J. Lewis, C. Jimenes-Rivera, et al., “Antikindling effects of LC stimulation: Mediation by ascending noradrenergic projections,” Exp. Neurol., 108, No. 1, 136–140 (1990).

    Article  PubMed  CAS  Google Scholar 

  28. J. Kayama, T. Negi, M. Sugitani, and K. Iwama, “Effects of locus coeruleus stimulation of neuronal activities of dorsal geniculate nucleus and perigeniculate reticular nucleus of the rat,” Neuroscience, 7, No. 5, 655–666 (1982).

    Article  PubMed  CAS  Google Scholar 

  29. Z. Nanobashvili, T. Chachua, A. Nanobashvili, et al., “Suppression of limbic seizures by electrical stimulation in thalamic reticular nucleus,” Exp. Neurol., 181, 224–230 (2003).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Center of Life Sciences, Tbilisi, Georgia

    Z. I. Nanobashvili, I. G. Bilanishvili, N. A. Khizanishvili & A. G. Koreli

  2. New York University School of Medicine, New York, USA

    T. R. Chachua & N. G. Nebieridze

Authors
  1. Z. I. Nanobashvili
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  2. T. R. Chachua
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  3. I. G. Bilanishvili
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  4. N. A. Khizanishvili
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  5. N. G. Nebieridze
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  6. A. G. Koreli
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Corresponding authors

Correspondence to Z. I. Nanobashvili or T. R. Chachua.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 43, No. 4, pp. 337–344, July–August, 2011.

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Nanobashvili, Z.I., Chachua, T.R., Bilanishvili, I.G. et al. Peculiarities of the Effects of Stimulation of Emotiogenic Central Structures under Conditions of a Kindling Model of Epilepsy. Neurophysiology 43, 292–298 (2011). https://doi.org/10.1007/s11062-011-9229-x

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  • DOI: https://doi.org/10.1007/s11062-011-9229-x

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