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Roles of different neurochemical systems in mechanisms underlying the antinociceptive effect of extrahigh-frequency electromagnetic radiation

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Abstract

We studied the effect of low-intensity extrahigh-frequency (EHF) electromagnetic radiation (EMR) on the duration of a pain behavioral reaction in rats under conditions of experimental induction of tonic pain (formalin test). The antinociceptive effect of EHF irradiation was modulated by suppression of the activity of a few neurochemical systems resulting from the blockade of receptors of opioid peptides, α-and β-adrenoreceptors, receptors of dopamine and melatonin, as well as from inhibition of serotonin synthesis. We demonstrated that all the respective neurochemical systems are to a certain extent involved in the mechanisms underlying the analgesic action of EHF EMR. Within an early phase of pain stress, functioning of the opioidergic and noradrenergic systems and the effects of melatonin play leading roles, while the activity of the serotonergic system plays such a role within the second (tonic) phase.

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Authors and Affiliations

  1. Vernadskii Tavricheskii National University, Simferopol’, Autonomic Republic of Crimea Ukraine

    E. N. Chuyan & É. R. Dzheldubayeva

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  1. E. N. Chuyan
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  2. É. R. Dzheldubayeva
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Correspondence to E. N. Chuyan.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 39, No. 2, pp. 165–173, March–April, 2007.

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Chuyan, E.N., Dzheldubayeva, É.R. Roles of different neurochemical systems in mechanisms underlying the antinociceptive effect of extrahigh-frequency electromagnetic radiation. Neurophysiology 39, 147–155 (2007). https://doi.org/10.1007/s11062-007-0020-y

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  • DOI: https://doi.org/10.1007/s11062-007-0020-y

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