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Contemporary management of pediatric spinal tumors: a single institute's experience in Taiwan in the modern era

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Abstract

Introduction

Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions.

Methods

A total of 75 pediatric patients with spinal tumors treated at the National Taiwan University Hospital from 1998 to 2018 were identified retrospectively. Clinical data, radiographic image, and pathological report were reviewed for analysis.

Results

There were 37 females and 38 males. The median age was 9 years. Thirty-eight tumors (50.6%) were extradural, 20 (26.7%) intradural extramedullary, and 17 (22.6%) intramedullary. The most common pathologies were glioma, ependymoma, and neuroblastoma. The rate of total and subtotal resection was 45.3% and 21.3%. Thirty-four patients (45.3%) required post-operative adjuvant therapy. Eight patients (10.6%) with spinal deformity had simultaneous tumor excision and spinal fusion surgery. Additional six (8%) patients had subsequent spinal fixation and fusion for deformity after primary tumor operation. Eighty-four percent of patients were ambulatory 3 years after operation. For patients with intradural extramedullary and intramedullary tumors, worse survival outcome was associated with tumor derived from CSF seeding and cranial involvement of spinal tumor, while poorer functional outcome was correlated with cranial involvement and adjuvant therapy with chemotherapy or radiotherapy.

Conclusions

Pediatric spinal tumor surgery carries low surgical morbidity and mortality under current standard of neurosurgical practice. Post-operative adjuvant therapy is required for nearly half of the cases. Spinal deformity requires special attention and sometimes surgical correction. Contemporary management of pediatric spinal tumors enables effective ablation of the lesion and delivers favorable outcome for the majority of patients.

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Acknowledgements

The authors acknowledge statistical assistance provided by the Center of Statistical Consultation and Research in the Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.

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Authors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan

    Sheng-Che Chou, Meng-Fai Kuo, Dar-Ming Lai, Chang-Mu Chen, Furen Xiao, Fon-Yih Tsuang & Shih-Hung Yang

  2. Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital Yun-Lin Branch, Douliou City, Yun-Lin County, Taiwan

    Sheng-Che Chou

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  1. Sheng-Che Chou
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Correspondence to Shih-Hung Yang.

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All procedures performed in the study involving human participants were in accordance with the ethical standards of the research ethics committee of the National Taiwan University Hospital, Taipei, Taiwan.

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Chou, SC., Kuo, MF., Lai, DM. et al. Contemporary management of pediatric spinal tumors: a single institute's experience in Taiwan in the modern era. J Neurooncol 146, 501–511 (2020). https://doi.org/10.1007/s11060-020-03400-3

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