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Preoperative grading of supratentorial nonenhancing gliomas by high b-value diffusion-weighted 3 T magnetic resonance imaging

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Abstract

The purpose of this study was to determine the difference in discrimination between high- and low-grade supratentorial nonenhancing gliomas (HGGs and LGGs, respectively) when using apparent diffusion coefficient (ADC) values with high or standard b-value. Thirty-nine patients underwent conventional magnetic resonance imaging and diffusion-weighted imaging (DWI) with standard and high b-values (b = 1000 and 3000 s/mm2, respectively). Minimum, maximum, and mean ADC values (ADCMIN, ADCMAX, and ADCMEAN, respectively) were measured from ADC maps with both b-values. Receiver operating curve analysis was used to determine the cutoff ADC values for distinguishing between nonenhancing HGGs and LGGs. ADCMIN, ADCMAX, and ADCMEAN values for the nonenhancing HGGs were lower than those for LGGs. These differences were much larger when a high b-value was used (all P < 0.0001) than when a standard b-value was used (P = 0.0001, <0.0001, and <0.0001, respectively). Discriminant analysis indicated that the greatest likelihood for discriminating HGGs and LGGs when ADCMEAN was obtained with a high b-value, with cutoff value of 0.814 × 10−3 mm2/s. ADC values obtained with a high b-value can be useful for grading and surgical management of nonenhancing HGGs and LGGs. The lowest degree of overlap was obtained when ADCMEAN was determined with a b-value of 3000 s/mm2.

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    Authors and Affiliations

    1. Department of Nuclear Medicine and Minnan PET Center, Xiamen Cancer Hospital, First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China

      Haiwei Han & Hua Wu

    2. Department of Neuroradiology, First Affiliated Hospital of Xiamen University, Xiamen, China

      Haiwei Han, Chengkun Han, Xiurong Wu & Xiongjie Zhuang

    3. Department of Neuropathology, First Affiliated Hospital of Xiamen University, Xiamen, China

      Shan Zhong

    4. Department of Neurosurgery, First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China

      Guowei Tan

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    1. Haiwei Han
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    This study was reviewed and approved by the review board of the First Affiliated Hospital of Xiamen University.

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    Haiwei Han and Chengkun Han have contributed equally to the work.

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    Han, H., Han, C., Wu, X. et al. Preoperative grading of supratentorial nonenhancing gliomas by high b-value diffusion-weighted 3 T magnetic resonance imaging. J Neurooncol 133, 147–154 (2017). https://doi.org/10.1007/s11060-017-2423-y

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    • DOI: https://doi.org/10.1007/s11060-017-2423-y

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