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Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron-emission tomography

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Abstract

The clinical course of meningioma varies from case to case, despite similar characteristics on magnetic resonance (MR) imaging. Functional imaging including 11C-methionine and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) has been widely studied for noninvasive preoperative evaluation of brain tumors. However, few reports have examined correlations between meningiomas and findings on 11C-methionine and FDG PET. The objective of this study was to clarify the relationship between tumor characteristics and 11C-methionine and FDG uptake in meningiomas. For 68 meningiomas in 51 cases, 11C-methionine uptake was evaluated by measuring both mean and maximum tumor/normal (T/N) ratio for the whole area of the tumors. FDG uptake in 44 of those meningiomas was also analyzed. Tumor size was measured volumetrically, and tumor-doubling time was estimated. Histopathological evaluation was performed in 19 surgical cases. Mean and maximum T/N ratios of 11C-methionine PET were significantly higher in skull-base lesions than in non-skull-base lesions. Correlations of mean and maximum T/N ratio of 11C-methionine PET with tumor-doubling time, MIB-1 labeling index, microvessel density and World Health Organization grading were not significant. Mean T/N ratio of 11C-methionine PET correlated significantly with tumor volume according to logarithm regression modeling (P < 0.0001, R = 0.544). However, mean and maximum T/N ratio of FDG-PET correlated with none of the tumor characteristics described above. These results suggest that 11C-methionine uptake correlates with tumor volume, but not with tumor aggressiveness.

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Acknowledgments

This work was supported in part by the Osaka Cancer Research Foundation, the Konica Minolta Imaging Science Foundation, the Osaka Cancer Researcher Training Fund, the Takeda Science Foundation, the Sagawa Foundation for Promotion of Cancer Research (all to Manabu Kinoshita, M.D., Ph.D.), and Grant-in-Aid no. 21791359 to Manabu Kinoshita, M.D., Ph.D., Grant-in-Aid no. 22659259 to Hideyuki Arita, M.D., Ph.D. for Scientific Research from the Ministry of Education, Science and Culture of Japan and Grant-in-Aid no. 22103508 for Scientific Research of Computational Anatomy from the Ministry of Education, Science, Sports, and Culture, Japan, to Naoya Hashimoto, M.D., Ph.D. The authors thank Ms Mariko Kakinoki (Department of Neurosurgery, Osaka University Graduate School Medicine) for her assistance in the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Hideyuki Arita, Manabu Kinoshita, Yoshiko Okita, Ryuichi Hirayama, Noriyuki Kijima, Naoki Kagawa, Yasunori Fujimoto, Haruhiko Kishima, Naoya Hashimoto & Toshiki Yoshimine

  2. Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Tadashi Watabe, Kayako Ishohashi, Eku Shimosegawa & Jun Hatazawa

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  1. Hideyuki Arita
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Correspondence to Manabu Kinoshita.

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Arita, H., Kinoshita, M., Okita, Y. et al. Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron-emission tomography. J Neurooncol 107, 379–386 (2012). https://doi.org/10.1007/s11060-011-0759-2

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  • DOI: https://doi.org/10.1007/s11060-011-0759-2

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