Skip to main content

Advertisement

SpringerLink
Log in

Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Summary

Aquaporins (AQPs) is a water channel family which facilitates the passage of water across cell membranes. Recently, expression of aquapporin 1 (AQP1) was found to be involved in not only water transport but also tumorigenesis. In present study, we analyzed the expression of AQP1 in 26 consecutive cases of human hemangioblastomas. Significant upregulation of AQP1 expression was found in hemangioblastomas compared with control brain (P=0.002). In hemangioblastomas, expression of AQP1 was predominantly localized on membranes of stromal cells. The expression level of AQP1 in cystic group of hemangioblastomas is much higher than that of solid group (P=0.021). Most hemangioblastomas showed a negative expression of AQP1 on endothelial cells. These results imply that increased expression of AQP1 in stromal cells may play a role in cyst formation and tumorigenesis of heman-gioblastomas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Niemela M, Lemeta S, Summanen P, Bohling T, Sainio M, Kere J, Poussa K, Sankila R, Haapasalo H, Kaariainen H, Pukkala E, Jaaskelainen J, Long-term prognosis of haemangioblastoma of the CNS: impact of von Hippel–Lindau disease Acta Neurochir (Wien) 141:1147–1156, 1999

    Article  CAS  Google Scholar 

  2. Resche F, Moisan JP, Mantoura J, de Kersaint-Gilly A, Andre MJ, Perrin-Resche I, Menegalli-Boggelli D, Lajat Y, Richard S, Haemangioblastoma, haemangioblastomatosis, and von Hippel–Lindau disease Adv Tech Stand Neurosurg 20:197–304, 1993

    PubMed  CAS  Google Scholar 

  3. Wanebo JE, Lonser RR, Glenn GM, Oldfield EH, The natural history of hemangioblastomas of the central nervous system in patients with von Hippel–Lindau disease J Neurosurg 98(1):82–94, 2003

    Article  PubMed  Google Scholar 

  4. Agre P, Kozono D, Aquaporin water channels: molecular mechanisms for human diseases FEBS Lett555(1):72–78, 2003

    Article  PubMed  CAS  Google Scholar 

  5. King LS, Kozono D, Agre P, From structure to disease: the evolving tale of aquaporin biology Nat Rev Mol Cell Biol. 5(9):687–698, 2004

    Article  PubMed  CAS  Google Scholar 

  6. Takata K, Matsuzaki T, Tajika Y, Aquaporins: water channel proteins of the cell membrane Prog Histochem Cytochem 39(1):1–83, 2004

    Article  PubMed  CAS  Google Scholar 

  7. Nicchia GP, Nico B, Camassa LM, Mola MG, Loh N, Dermietzel R, Spray DC, Svelto M, Frigeri A, The role of aquaporin-4 in the blood–brain barrier development and integrity: studies in animal and cell culture models Neuroscience129(4):935–945, 2004

    Article  PubMed  CAS  Google Scholar 

  8. Sulyok E, Vajda Z, Doczi T, Nielsen S, Aquaporins and the central nervous system Acta Neurochir (Wien) 146(9):955–960, 2004

    Article  CAS  Google Scholar 

  9. Venero JL, Machado A, Cano J, Importance of aquaporins in the physiopathology of brain edema. Curr Pharm Des 10(18):2153–2161, 2004

    Article  PubMed  CAS  Google Scholar 

  10. Oshio K, Binder DK, Liang Y, Bollen A, Feuerstein B, Berger MS, Manley GT, Expression of the aquaporin-1 water channel in human glial tumors. Neurosurgery 56(2):375–381, 2005

    Article  PubMed  Google Scholar 

  11. Moon C, Soria JC, Jang SJ, Lee J, Obaidul Hoque M, Sibony M, Trink B, Chang YS, Sidransky D, Mao L, Involvement of aquaporins in colorectal carcinogenesis Oncogene 22(43):6699–6703, 2003

    Article  PubMed  CAS  Google Scholar 

  12. Benech F, Perez R, Fontanella MM, Morra B, Albera R, Ducati A, Cystic versus solid vestibular schwannomas: a series of 80 grade III-IV patients Neurosurg Rev28(3):209–213, 2005

    Article  PubMed  Google Scholar 

  13. Tali ET, Yuh WT, Nguyen HD, Feng G, Koci TM, Jinkins JR, Robinson RA, Hasso AN, Cystic acoustic schwannomas: MR characteristics Am J Neuroradiol 14:1241–1247, 1993

    PubMed  CAS  Google Scholar 

  14. Stamer WD, Bok D, Hu J, Jaffe GJ, McKay BS, Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement Invest Ophthalmol Vis Sci44(6):2803–2808, 2003

    Article  PubMed  Google Scholar 

  15. Endo M, Jain RK, Witwer B, Brown D, Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas Microvasc Res58(2):89–98, 1999

    Article  PubMed  CAS  Google Scholar 

  16. Saadoun S, Papadopoulos MC, Davies DC, Bell BA, Krishna S, Increased aquaporin 1 water channel expression in human brain tumours Br J Cancer87(6):621–631, 2002

    Article  PubMed  CAS  Google Scholar 

  17. Cruz-Sanchez FF, Rossi ML, Rodriguez-Prados S, Nakamura N, Hughes JT, Coakham HB, Haemangioblastoma: histological and immunohistological study of an enigmatic cerebellar tumour Histol Histopathol5(4):407–413, 1990

    PubMed  CAS  Google Scholar 

  18. Grant JW, Gallagher PJ, Hedinger C, Haemangioblastoma. An immunohistochemical study of ten cases Acta Neuropathol (Berl) 76(1):82–86, 1988

    Article  CAS  Google Scholar 

  19. Ironside JW, Stephenson TJ, Royds JA, Mills PM, Taylor CB, Rider CC, Timperley WR, Stromal cells in cerebellar haemangioblastomas: an immunocytochemical study Histopathology 12(1):29–40, 1988

    PubMed  CAS  Google Scholar 

  20. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS, Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption Nature 434(7034):786–792, 2005

    Article  PubMed  CAS  Google Scholar 

  21. Splinter PL, Masyuk AI, LaRusso NF, Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs J Biol Chem278(8):6268–6274, 2003

    Article  PubMed  CAS  Google Scholar 

  22. Moon C, King LS, Agre P, Aqp1 expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction Am J Physiol273(5 Pt 1):C1562–C1570, 1997

    PubMed  CAS  Google Scholar 

  23. Umenishi F, Schrier RW, Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene J Biol Chem278(18):15765–15770, 2003

    Article  PubMed  CAS  Google Scholar 

  24. Julow J, Balint K, Gortvai P, Pasztor E, Posterior fossa haemangioblastomas Acta Neurochir (Wien)128(1–4):109–114, 1994

    Article  CAS  Google Scholar 

  25. Young S, Richardson AE, Solid haemangioblastomas of the posterior fossa: radiological features and results of surgery J Neurol Neurosurg Psychiatry 50(2):155–158, 1987

    Article  PubMed  CAS  Google Scholar 

  26. Yamashita J, Handa H, Kim C, Kim S, Familial occurrence of cerebellar hemangioblastomas – analysis of five families Neurosurgery 11(6):761–763, 1982

    PubMed  CAS  Google Scholar 

  27. Lohle PN, Verhagen IT, Teelken AW, Blaauw EH, Go KG, The pathogenesis of cerebral gliomatous cysts Neurosurgery 30(2):180–185, 1992

    PubMed  CAS  Google Scholar 

  28. Papadopoulos MC, Manley GT, Krishna S, Verkman AS, Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema FASEB J 18(11):1291–1293, 2004

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We are deeply indebted to Akiko Imamura for helping with sample collection. This work was supported by Japanese Ministry of Education, Culture, Sports, Science and Technology.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan

    Yizhao Chen, Osamu Tachibana, Jun-ichiro Hamada & Junkoh Yamashita

  2. Department of Neurosurgery, Pearl River Hospital, South Medical University, Guangzhou, China

    Ruxiang Xu

  3. Department of Neurosurgery Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Yizhao Chen, Masashi Oda, Nobuo Hashimoto & Jun A. Takahashi

Authors
  1. Yizhao Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Osamu Tachibana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masashi Oda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ruxiang Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jun-ichiro Hamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Junkoh Yamashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nobuo Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jun A. Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun A. Takahashi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, Y., Tachibana, O., Oda, M. et al. Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation. J Neurooncol 80, 219–225 (2006). https://doi.org/10.1007/s11060-005-9057-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-005-9057-1

Keywords

Search

Navigation