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Proposal of a scoring scale as a survival predictor in intracranial oligodendrogliomas

  • Clinical-patient studies
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Journal of Neuro-Oncology Aims and scope Submit manuscript

Summary

Introduction

Histological, clinical and radiological features, and molecular genetic analysis are among the factors that have been considered in defining the prognosis of oligodendrogliomas (OD), but they have yielded conflicting results.

The purpose of this study was to test out a scoring scale based on clinical, radiological, pathological and molecular features.

Material and method

To identify factors with prognostic significance, we analyzed 87 treated patients with a histological diagnosis of OD. Of the parameters analyzed, age, onset, clinical status, radiological enhancement, histological necrosis, mitosis and chromosomal anomalies emerged as significant prognosis factors using univariate analysis. Multivariate analysis revealed age and chromosomal anomalies as independent factors of survival.

Results

The factors with a significant prognostic value were combined to determine which grouping factors best predict outcome. The proposed score is a pure number resulting from a combination of: 2 major factors: age and chromosomal anomalies (scored 3–0); 5 minor factors: onset, clinical examination, necrosis, mitoses (scored 1–0), and radiological enhancement (scored 2–0). According to our scale, 10 survival curves were produced for overall survival. Recursive partitioning of patients with the nearest score and outcome produced four groups with a significant difference in survival (p=10−5). The power of both the scale and the partitioned groups for predicting outcome was more accurate than the WHO and St Anne grading systems, and the molecular sub-classification.

Conclusions

Our scale is a plausible way of classifying patients harboring intracranial OD according to expected survival.

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Acknowledgements

We are grateful to Abed El-Ghalem for his help and advice and Ms. T. Westcott for correcting the English. In memory of Larbi Hamlat.

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Authors and Affiliations

  1. Department of Neurosurgery, CHU Pontchaillou, Rennes, France

    Abderrahmane Hamlat & Yvon Guegan

  2. Departments of Pathology, CHU Pontchaillou, Rennes, France

    Stephan Saikali

  3. Departments of Public Health, CHU Pontchaillou, Rennes, France

    Jacques Chaperon

  4. Departments of Radiology, CHU Pontchaillou, Rennes, France

    Beatrice Carsin-Nicol

  5. Department of Cytogenetic and Molecular Biology, CHU Pontchaillou, Rennes, France

    Michéle Le Calve

  6. Departments of Medical Oncology, Centre Eugene Marquis, Rennes, France

    Thierry Lesimple

  7. Departments of Radiotherapy, Centre Eugene Marquis, Rennes, France

    Mohamed Ben-hassel

  8. Service de neurochirurgie, CHRU Pontchaillou, Rue Henri Le Guilloux, 35000, Rennes Cedex 2, France

    Abderrahmane Hamlat

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  1. Abderrahmane Hamlat
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Correspondence to Abderrahmane Hamlat.

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Hamlat, A., Saikali, S., Chaperon, J. et al. Proposal of a scoring scale as a survival predictor in intracranial oligodendrogliomas. J Neurooncol 79, 159–168 (2006). https://doi.org/10.1007/s11060-005-9026-8

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  • DOI: https://doi.org/10.1007/s11060-005-9026-8

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