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Patterns of Functional Connectivity in the Brain in Temporal and Frontal Epilepsy

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Objectives. To identify the pattern of functional connectivity (FC) between areas and networks in the brain in patients with frontal and temporal foci of epileptic activity. Materials and methods. A total of 43 patients aged 18–50 years with focal epilepsy – 32 with temporal epilepsy (TE) and 11 with frontal epilepsy (FE) – were studied. The control group consisted of 32 healthy subjects. The main method used in the study was brain MRI scans run using the epilepsy protocol and additionally including high-resolution structural images of the brain, along with resting-state fMRI. Results and conclusions. The most marked fMRI feature in patients with TE as compared with healthy subjects was a decrease in the FC of the insular cortex and the temporal opercula (the part of the temporal gyrus of each hemisphere overhanging the insula). In left-sided FE, the decrease on the left was significant. Increased FC in the dorsal part of the attention network on the left with the temporal and parietal areas of the cerebral cortex was specific for right-sided TE. TE also produced a decrease in FC between the anterior part of the cingulate gyrus and the basal ganglia. All significant results were linked with increases in FC in patients with FE as compared with healthy subjects, maximally in areas of the temporal cortex. Thus, the localization and lateralization of the focus of epileptic activity determine the pattern of FC in these areas and neural networks of the brain in patients with focal epilepsy.

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    I. S. Samotaeva & N. N. Lebedeva

  2. Solov’ev Scientific and Practical Center for Psychoneurology, Moscow Health Department, Moscow, Russia

    I. S. Samotaeva, A. M. Teplyshova, F. K. Rider, Yu. V. Solomatin, R. V. Luzin, N. N. Lebedeva & A. B. Guekht

  3. Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow, Russia

    A. B. Guekht

Authors
  1. I. S. Samotaeva
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  2. A. M. Teplyshova
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  3. F. K. Rider
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  4. Yu. V. Solomatin
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  5. R. V. Luzin
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  6. N. N. Lebedeva
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  7. A. B. Guekht
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Correspondence to I. S. Samotaeva.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 119, No. 11, Iss. 2, pp. 11–15, November, 2019.

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Samotaeva, I.S., Teplyshova, A.M., Rider, F.K. et al. Patterns of Functional Connectivity in the Brain in Temporal and Frontal Epilepsy. Neurosci Behav Physi 50, 835–840 (2020). https://doi.org/10.1007/s11055-020-00975-2

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  • DOI: https://doi.org/10.1007/s11055-020-00975-2

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