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Interaction of Depression and Anxiety in the Development of Mixed Anxiety/Depression Disorder. Experimental Studies of the Mechanisms of Comorbidity (review)

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The symptoms of depression and anxiety often accompany each other. This is apparent both in clinical practice and in laboratory studies. The combination of anxiety and depression in humans responds more slowly to treatment, requires higher doses of drugs, and increases the probability of suicide and the frequency of recurrences. In addition, existing antidepressants and anxiolytics exert their therapeutic effects even in the monopolar development of anxiety or depression in only a limited number of cases. This review of the literature and our own data analyzes the relationship between anxiety and depression. Psychotropic drugs with different spectra of action in a model of mixed anxiety/depression disorder induced by chronic social stress in male mice showed that the states of anxiety and depression change independently in response to anxiolytics and antidepressants.

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Authors and Affiliations

  1. Neuropathology Modeling Laboratory, Neurogenetics of Social Behavior Sector, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    A. G. Galyamina, I. L. Kovalenko, D. A. Smagin & N. N. Kudryavtseva

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  1. A. G. Galyamina
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  2. I. L. Kovalenko
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  3. D. A. Smagin
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  4. N. N. Kudryavtseva
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Correspondence to N. N. Kudryavtseva.

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 66, No. 2, 181–201, March–April, 2016.

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Galyamina, A.G., Kovalenko, I.L., Smagin, D.A. et al. Interaction of Depression and Anxiety in the Development of Mixed Anxiety/Depression Disorder. Experimental Studies of the Mechanisms of Comorbidity (review). Neurosci Behav Physi 47, 699–713 (2017). https://doi.org/10.1007/s11055-017-0458-3

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  • DOI: https://doi.org/10.1007/s11055-017-0458-3

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