The individual characteristics of cognitive behavior induced by intracerebroventricular administration of aggregated amyloid β-peptide (25–35) (Aβ25–35) were studied. A new approach to evaluating individual features of the actions of Aβ25–35 was used. Navigational training was performed in a single brief session using random target positions, and training sessions were repeated a few days later. These experiments produced the first indication that cognitive behavior was undamaged in 50% of the rats at the early stage of Aβ25–35 exposure. The activities of the antioxidant enzymes superoxide dismutase and catalase in the cortex and hippocampus were significantly decreased in animals with and without cognitive impairments. We suggest that phenotypic characteristics may underlie the individual features of the animals’ responses to Aβ. At the early stage, aggregated Aβ may induce a compensatory reaction which prevents impairment of cognitive processes.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 59, No. 5, pp. 616–621, September–October, 2009.
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Mugantseva, E.A., Podolskii, I.Y. Central Administration of Amyloid β-Peptide (25–35) and Individual Features of Cognitive Behavior in Rats. Neurosci Behav Physi 40, 964–968 (2010). https://doi.org/10.1007/s11055-010-9353-x
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DOI: https://doi.org/10.1007/s11055-010-9353-x