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Current and evolving knowledge domains of cubosome studies in the new millennium

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Abstract

Cubosomes have aroused growing interest recently due to their widespread applications in pharmaceutical, food, cosmetic industries, etc. Especially, they demonstrate many advantages as drug delivery systems. However, no pharmaceutical products have been translated from bench to bedside so far. To promote the translation of the drug delivery system candidate, it is significant to accumulate fundamental and applied-fundamental knowledge of cubosomes. In the study, a bibliometric study upon cubosome research was carried out on the basis of Web of Science Core Collection database to figure out current and evolving knowledge domains of the published studies in a logical and robust way, summarizing the status quo and pointing out the future directions of cubosome research. Four questions which are pending addressed were answered by applying this research method and some conclusions were drawn: (1) Australia could be viewed as the most productive contributor for cubosome research. (2) Langmuir might be the most influential publishing media. (3) Using cubosomes as drug delivery carriers was a hot topic. (4) Adopting cubosomes as ocular drug delivery vehicles would continue to be a frequently studied aspect. In addition, cubosomes serve as alternative vector deliver active pharmaceutical ingredients to the brain and encapsulate active components extracted from herbal and traditional medicines in cubosomes are the burgeoning trends. By answering the four questions, productive contributors, influential publishing media, current research foci, and future directions were figured out. Hence, the current and evolving knowledge domains of cubosome studies were illustrated.

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Funding

This work was supported by China Postdoctoral Science Foundation Special Funded Project [grant number 2022T150268] and Guangzhou Science and Technology Plan Project [grant number 202201010589].

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Author notes

  1. Ying Huang, Ziyao Chang, and Xiao Xia contributed equally to this review.

Authors and Affiliations

  1. College of Pharmacy, Jinan University, Guangzhou, 510006, People’s Republic of China

    Ying Huang, Xiao Xia, Xuejuan Zhang, Zhengwei Huang & Chuanbin Wu

  2. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People’s Republic of China

    Ziyao Chang & Xin Pan

  3. Department of Pharmacy, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, 510220, China

    Ziyu Zhao

Authors
  1. Ying Huang
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  2. Ziyao Chang
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  3. Xiao Xia
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  4. Ziyu Zhao
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  5. Xuejuan Zhang
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  6. Zhengwei Huang
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  7. Chuanbin Wu
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  8. Xin Pan
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Contributions

Ying Huang: Conceptualization, Methodology. Ziyao Chang: Writing-Original draft preparation. Xiao Xia: Writing-Original draft preparation, Data curation. Ziyu Zhao: Data curation. Xuejuan Zhang: Investigation. Zhengwei Huang: Validation. Chuanbin Wu: Funding acquisition, Project administration. Xin Pan: Supervision.

Corresponding authors

Correspondence to Xuejuan Zhang, Zhengwei Huang or Xin Pan.

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Huang, Y., Chang, Z., Xia, X. et al. Current and evolving knowledge domains of cubosome studies in the new millennium. J Nanopart Res 25, 176 (2023). https://doi.org/10.1007/s11051-023-05823-1

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