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Effect of synthesis conditions on local atomic structure and properties of low-toxic maghemite nanoparticles for local magnetic hyperthermia in oncology

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Abstract

Low-toxic colloidal superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications were obtained by microwave-assisted technique. Nanoparticles were synthesized by the hydrothermal method under different conditions. XANES, XRD, and XPS studies support the maghemite (γ-Fe2O3) atomic and electronic structure of the nanoparticles. XANES data analysis reveals that nanoparticles have the structure reminiscent of the macroscopic maghemite. Mossbauer spectroscopy supports the γ-Fe2O3 phase of the nanoparticles and vibration magnetometry study shows that the nanoparticles appear to be superparamagnetic. Nanoparticle shape and size were studied by TEM and DLS methods. It was shown that the nanoparticles do not exceed 20 nm. Also, the nanoparticles are found to be low-toxic and did not have significant effects on the viability of the HeLa cell culture. The obtained nanoparticles generated heat with the highest ILP value of 2.56 nHm2/kg and can be considered potential candidates as heat mediators for local magnetic hyperthermia in oncology.

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Acknowledgements

The XANES experiments were performed at beamline ID26 of European Synchrotron Radiation Facility (ESRF), Grenoble, France.

Funding

This research was financially supported by the Ministry of Science and Higher Education of the Russian Federation (state assignment in the field of scientific activity, № 0852–2020-0019).

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Author notes

  1. Elena A. Kuchma and Alexander V. Soldatov contributed equally to this work.

Authors and Affiliations

  1. The Smart Materials Research Institute at the Southern Federal University, Sladkova 178, Rostov-on-Don, 344090, Russia

    Elena A. Kuchma, P. V. Zolotukhin, A. A. Belanova, M. A. Soldatov, O. E. Polozhentsev, P. V. Medvedev & Alexander V. Soldatov

  2. Research Institute of Physics, Southern Federal University, Rostov-on-Don, Russia

    A. T. Kozakov & S. P. Kubrin

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  1. Elena A. Kuchma
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Correspondence to Elena A. Kuchma or Alexander V. Soldatov.

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Kuchma, E.A., Zolotukhin, P.V., Belanova, A.A. et al. Effect of synthesis conditions on local atomic structure and properties of low-toxic maghemite nanoparticles for local magnetic hyperthermia in oncology. J Nanopart Res 24, 25 (2022). https://doi.org/10.1007/s11051-021-05393-0

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