Abstract
In this study, we presented a simple approach to prepare hydroxyethylated graphene oxide (HE-GO) with high water solubility and physiological stability. The successful synthesis of HE-GO was confirmed by UV–Vis spectroscopy, Fourier transform infrared spectroscopy, and atomic force microscopy. The loading of anticancer drug methotrexate (MTX) onto this nanocarrier (MTX/HE-GO) was investigated. The results of in vitro drug release experiment showed that the rate of MTX release from MTX/HE-GO was pH dependent. Moreover, cell viability assay demonstrated that HE-GO loaded with MTX exhibits higher anticancer activity against human lung adenocarcinoma epithelial cell line than non-vehicle MTX.
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Acknowledgments
This project was supported by the National Natural Science Foundation of China (Nos. 91227122 & 90813021).
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Du, L., Suo, S., Luo, D. et al. Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery. J Nanopart Res 15, 1708 (2013). https://doi.org/10.1007/s11051-013-1708-0
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DOI: https://doi.org/10.1007/s11051-013-1708-0