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Controlled release of ketorolac through nanocomposite films of hydrogel and LDH nanoparticles

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Abstract

A novel nanocomposite film for sustained release of anionic ophthalmic drugs through a double-control process has been examined in this study. The film, made as a drug-loaded contact lens, consists principally of a polymer hydrogel of 2-hydroxyethyl methacrylate (HEMA), in whose matrix MgAl-layered double hydroxide (MgAl-LDH) nanoparticles intercalated with the anionic drug are well dispersed. Such nanocomposite films (hydrogel-LDH-drug) contained 0.6–0.8 mg of MgAl-LDH and 0.08–0.09 mg of the ophthalmic drug (ketorolac) in 1.0 g of hydrogel. MgAl-drug-LDH nanoparticles were prepared with the hydrodynamic particle size of 40–200 nm. TEM images show that these nanoparticles are evenly dispersed in the hydrogel matrix. In vitro release tests of hydrogel-LDH-drug in pH 7.4 PBS solution at 32 °C indicate a sustained release profile of the loaded drug for 1 week. The drug release undergoes a rapid initial burst and then a monotonically decreasing rate up to 168 h. The initial burst release is determined by the film thickness and the polymerization conditions, but the following release rate is very similar, with the effective diffusion coefficient being nearly constant (3.0 × 10−12 m2/s). The drug release from the films is mechanistically attributed to anionic exchange and the subsequent diffusion in the hydrogel matrix.

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Acknowledgments

Funding from the Australian Research Council for the ARC Centre of Excellence for Functional Nanomaterials and ARC Discovery project (DP0879769) is gratefully acknowledged.

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Authors and Affiliations

  1. Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence for Functional Nanomaterials, The University of Queensland, Brisbane, QLD, 4072, Australia

    Zhi Ping Xu, Zi Gu, Xiaoxi Cheng & Gao Qing Max Lu

  2. Centre for Advanced Imaging and Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia

    Firas Rasoul & Andrew K. Whittaker

Authors
  1. Zhi Ping Xu
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  2. Zi Gu
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  3. Xiaoxi Cheng
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  4. Firas Rasoul
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  5. Andrew K. Whittaker
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  6. Gao Qing Max Lu
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Correspondence to Zhi Ping Xu or Gao Qing Max Lu.

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Xu, Z.P., Gu, Z., Cheng, X. et al. Controlled release of ketorolac through nanocomposite films of hydrogel and LDH nanoparticles. J Nanopart Res 13, 1253–1264 (2011). https://doi.org/10.1007/s11051-010-0118-9

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  • DOI: https://doi.org/10.1007/s11051-010-0118-9

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