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Mesoporous silica-coated NaYF4:Yb3+, Er3+ particles for drug release

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Abstract

NaYF4:Yb3+, Er3+ nanoparticles were successfully prepared by a polyol process using diethyleneglycol (DEG) as solvent. These NaYF4:Yb3+, Er3+ nanoparticles can be coated with mesoporous silica using nonionic triblock copolymer EO20PO70EO20 (P 123) as structure-directing agent and other materials. The composites can load ibuprofen and release the drug in the phosphate buffer solution (PBS). The composites were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption/desorption isotherms, fluorescence spectra, and UV/Vis absorption spectra, respectively. The composites have the mesoporous structure. In addition, the composites emit red fluorescence (from Er3+) under 980 nm near infrared laser excitation, which can be used as fluorescent probes in the drug-delivery system.

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Acknowledgments

This project is financially supported by the National Basic Research Program of China (2007CB935502) and the National Natural Science Foundation of China (NSFC 50702057, 50872131, 00610227).

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Authors and Affiliations

  1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People’s Republic of China

    Deyan Kong, Yong Fan, Cuimiao Zhang & Jun Lin

  2. Graduate School of the Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China

    Deyan Kong

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  1. Deyan Kong
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  2. Yong Fan
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  3. Cuimiao Zhang
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  4. Jun Lin
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Correspondence to Jun Lin.

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Kong, D., Fan, Y., Zhang, C. et al. Mesoporous silica-coated NaYF4:Yb3+, Er3+ particles for drug release. J Nanopart Res 12, 663–673 (2010). https://doi.org/10.1007/s11051-009-9635-9

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  • DOI: https://doi.org/10.1007/s11051-009-9635-9

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