Abstract
Lifestyle modification can lead to numerous health issues closely associated with sleep. Sleep deprivation and disturbances significantly affect inflammation, immunity, neurodegeneration, cognitive depletion, memory impairment, neuroplasticity, and insulin resistance. Sleep significantly impacts brain and memory formation, toxin excretion, hormonal function, metabolism, and motor and cognitive functions. Sleep restriction associated with insulin resistance affects these functions by interfering with the insulin signalling pathway, neurotransmission, inflammatory pathways, and plasticity of neurons. So, in this review, We discuss the evidence that suggests that neurodegeneration occurs via sleep and is associated with insulin resistance, along with the insulin signalling pathways involved in neurodegeneration and neuroplasticity, while exploring the role of hormones in these conditions.
Graphical Abstract
Highlights
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Insulin resistance increases the accumulation of amyloid β, tau, and synuclein in neurons, leading to neurodegeneration.
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The insulin signalling pathway has a potential role in sleep deprivation-induced insulin resistance.
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Neurohormones that play a role in the sleep/wake cycle modulate insulin sensitivity, metabolism, and neurodegeneration.
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References
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Ramasubbu, K., Ramanathan, G., Venkatraman, G. et al. Sleep-associated insulin resistance promotes neurodegeneration. Mol Biol Rep 50, 8665–8681 (2023). https://doi.org/10.1007/s11033-023-08710-z
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DOI: https://doi.org/10.1007/s11033-023-08710-z