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The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis

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Abstract

The association between CD14 gene C-159T polymorphism and tuberculosis (TB) susceptibility remains inconclusive. To derive a more precise estimation of the correlation, we performed a meta-analysis summarize the possible at a systematic manner. PubMed, HighWire and ScienceDirect databases covering all papers (up to November 2012) were searched. Statistical analyses were conducted by Rev-Man and STATA. Random- and fixed-effect models were used to estimate pooled odds ratios (ORs) and 95 % confidence intervals (CIs), based on between-study heterogeneity. Eight published case–control studies investigating the relationship between C-159T polymorphism in CD14 gene and TB susceptibility were included. Results showed that individuals with T allele have an increased risk of TB compared with those with C allele (OR (95 % CI) was 1.52 (1.11, 2.08) for TT vs. TC + CC, P < 0.001; 1.27 (1.01, 1.61) for T vs. C, P = 0.04). When stratified by ethnicity, variant TT homozygote carriers had an 86 % increased risk of TB in Asians (OR (95 % CI) was 1.86 (1.57, 2.20) for TT vs. TC + CC, P < 0.001), but not in Caucasians (OR (95 % CI) was TT vs. TC + CC: OR = 0.78, 95 % CI = 0.51–1.21, P = 0.61). This meta-analysis suggests that C-159T polymorphism in CD14 gene is associated with increased risk of TB, especially in Asians, but not in Caucasians.

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Authors and Affiliations

  1. Songgang Health Inspection and Prevention Institute, Shenzhen, China

    Qing Yuan, Huifang Chen, Xiaming Chen, Qun Li, Yanping Zhang & Xiaorong Zhang

  2. Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China

    Huifang Chen, Xueyan Zheng, Tingli Shi, Junhua Zhou, Qing Chen & Shouyi Yu

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  1. Qing Yuan
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Correspondence to Shouyi Yu.

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Yuan, Q., Chen, H., Zheng, X. et al. The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis. Mol Biol Rep 41, 7623–7629 (2014). https://doi.org/10.1007/s11033-014-3652-1

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