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The association between KL polymorphism and prostate cancer risk in Korean patients

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Abstract

The Klotho (KL) gene is a classical “aging suppressor” gene. Although recent studies have shown that KL participates in the progression of several types of human cancers, the relationship between KL polymorphism and prostate cancer was unknown. The present study aimed to investigate the association between KL genetic polymorphisms and prostate cancer. Twenty-five common single nucleotide polymorphisms (SNPs) in KL gene (including KL gene polymorphism C1818T in exon 4) were assessed in 272 prostate cancer cases and 173 controls. Single-locus analyses were conducted using unconditional logistic regression. In addition, we did a haplotype analysis for the 25 KL SNPs tested. CC genotype of C1548T KL polymorphism had approximately twofold increased prostate cancer risk compared with the homozygous genotype TT and heterozygote CT (odds ratio 1.85 [95 % CI, 1.09–3.12], P = 0.02). We also found that non-T allele carriers had significantly higher prostate cancer risk associated with the prostate cancer clinical characteristics (tumor stage or Gleason score). Our findings suggested that the C1548T polymorphism of KL gene is associated with the prostate cancer and may act as a risk factor for the development of prostate cancer.

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Acknowledgments

This work was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare & Family Affairs, Republic of Korea (A085138) and by Grant No. 03-2010-012 from the SNUBH Research Fund.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, 156-756, Korea

    Hae Jong Kim, Jaehyouk Lee, Wonyong Kim & Soon Chul Myung

  2. Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, 156-756, Korea

    Hae Jong Kim, Jaehyouk Lee, Wonyong Kim & Soon Chul Myung

  3. Department of Urology, Seoul Medical Center, Seoul, 131-865, Korea

    Shin Young Lee

  4. Department of Genetic Epidemiology, SNP Genetics Inc, Seoul, 121-742, Korea

    Hyun Sub Cheong

  5. Department of Chemistry, Korea Military Academy, Seoul, 139-799, Korea

    Young-Sik Kye

  6. Department of Microbiology, Chung-Ang University College of Medicine, Seoul, 156-756, Korea

    Wonyong Kim

  7. Department of Urology, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Korea

    Seok-Soo Byun

  8. Department of Urology, Chung-Ang University College of Medicine, 221 Heuksuk-dong Dongjak-gu, Seoul, 156-756, Korea

    Soon Chul Myung

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  1. Hae Jong Kim
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Correspondence to Seok-Soo Byun or Soon Chul Myung.

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Kim, H.J., Lee, J., Lee, S.Y. et al. The association between KL polymorphism and prostate cancer risk in Korean patients. Mol Biol Rep 41, 7595–7606 (2014). https://doi.org/10.1007/s11033-014-3647-y

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  • DOI: https://doi.org/10.1007/s11033-014-3647-y

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