Abstract
Rising levels of obesity are a global problem that is being exported from affluent to developing nations through the gradual “westernization of lifestyle”. Population of Saudi Arabia is going through a nutrition transition where customary and traditional food is being replaced by fast food high in fat, sugar and salt. Interleukin-6 (IL-6) is a central player in the regulation of inflammation, haematopoiesis, immune response and host defense mechanisms. During the last decade, an accumulating amount of data suggested a pivotal role for IL-6 in metabolic processes, thus fortifying the picture of IL-6 as a multifaceted, pleiotropic cytokine. The Objective is to investigate the relationship between IL-6 (rs1554606) polymorphism and the risk of obesity in young Saudi population. Totally 204 Saudi young obese subjects were involved in this study. Genotyping of IL-6 was performed by the real-time polymerase chain reaction technology, using the Taq Man 5′-allele discrimination assay. IL-6 (rs1554606) AA versus AG (p < 0.01) and AA versus GG (p < 0.01) shows significant difference between Male and female group in genotypic as well as allelic distribution differ significantly, while AG versus GG did not differ significantly (p > 0.5). We have observed significant effects for Genotyping, LDL, CHOL, AST, ALP, BILIT, BMI at 5 % (0.05) significance level in the study population. Our results shown that IL-6 polymorphism have significantly differ in both male and females subjects. We have observed that some evidence of interactions of the IL-6 polymorphism and have shown statistical significant association with elevated BMI, Lipid profile and total bilurubin in the study subjects.
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Acknowledgment
The authors would like to extend their sincere appreciation to the Deanship of Scientific Research Centre at King Saud University for its funding of this research work through the Research Group Project No. RGP-VPP-244. There are no financial or personal conflicting interests raised from this study.
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Alharbi, K.K., Syed, R. & Khan, I.A. Association of interleukin-6 polymorphisms with obesity and metabolic alterations in young Saudi population. Mol Biol Rep 41, 1519–1523 (2014). https://doi.org/10.1007/s11033-013-2997-1
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DOI: https://doi.org/10.1007/s11033-013-2997-1