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Lipoic acid attenuates the expression of adhesion molecules by increasing endothelial nitric-oxide synthase activity

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Abstract

We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothelial cells were exposed to high glucose in the absence and presence of LA. Coincubation of endothelial cells with high glucose for 24 h resulted in a significant increase of monocyte–endothelial cell adhesion and the expression of ICAM-1 (P < 0.01). These effects were abolished by LA and LA significantly increased eNOS activities (P < 0.01). These findings suggested that LA may play a role in inhibiting expression of adhesion molecules by increasing eNOS activities.

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Acknowledgments

This study was supported by the Youth Science and Technology Special Foundation of Heilongjiang Province (QC06C060), Medical Basic Subjects Youth Science Foundation of Harbin Medical University (060014) and Science and Technology Foundation of Heilongjiang Provincial Health Department (2006-472) and Nature and Science Foundation of Heilongjiang Province of People's Republic of China (D201115).

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The authors have stated that they have no interests which might be perceived as causing a conflict or a bias.

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Authors and Affiliations

  1. Department of Physiology, Harbin Medical University, 194 Xuefu Rd., Nangang District, Harbin, 150081, People’s Republic of China

    Hong-Bo Jin, Yong-Bin Yang, Ying-Li Song, Yong-chun Zhang & Yu-Rong Li

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  1. Hong-Bo Jin
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  2. Yong-Bin Yang
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Correspondence to Yu-Rong Li.

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Hong-Bo Jin and Yong-Bin Yang contributed equally to this study.

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Jin, HB., Yang, YB., Song, YL. et al. Lipoic acid attenuates the expression of adhesion molecules by increasing endothelial nitric-oxide synthase activity. Mol Biol Rep 40, 377–382 (2013). https://doi.org/10.1007/s11033-012-2071-4

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  • DOI: https://doi.org/10.1007/s11033-012-2071-4

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